Objectives: To test whether early treatment with a high initial dose of levothyroxine can
prevent suboptimal mental development in all neonates with congenital hypothyroidism …

To evaluate the effect of different initial levothyroxine (LT4) replacement doses on growth
and intellectual outcome in patients with congenital hypothyroidism (CH) detected by …

OBJECTIVES: To compare neurodevelopmental outcomes in severe and moderate
congenital hypothyroidism (CH) among 3 different initial L-thyroxine doses and to examine …

OBJECTIVES: To evaluate the influence of initial and postinitial treatment factors on
cognitive, psychomotor, and psychological outcome in schoolchildren with congenital …

Objective: To determine between timing and LT4 dose which was the more important factor
for IQ at 7 years in screened congenital hypothyroidism (CH). Methods: 131 children with CH …

We have previously reported that despite neonatal screening, children with severe
congenital hypothyroidism treated at 5 weeks of age with 6 micrograms/kg. day …

Neonatal screening programs for congenital hypothyroidism (CH) were initiated in the 1970s
to ensure early treatment in order to prevent mental retardation. With screening …

Early detection by newborn screening and appropriate L-thyroxine treatment leads to normal
or near-normal neurocognitive outcome in infants with congenital hypothyroidism. Many …

Objectives: To determine the optimal initial treatment dose of L-thyroxine in congenital
hypothyroidism (CH) by evaluating the time course of rise of thyroxine (T4) and free T4 …

Objective. To compare the effects of therapy with thyroxine (T4) plus triiodothyronine (T3)
versus T4 alone from the first days of life in screened congenital hypothyroid (CH) infants …