Nitrogen-containing compounds are the most common structural architectures in drug
candidates, natural and biological products, and small-molecule therapeutics. Within the …

The formation of carbon–nitrogen bonds by reaction between a nitrogen atom and an
unactivated carbon–hydrogen bond is a highly atom-economical process that attracted the …

DFT calculations have been combined with experiments to study the mechanism of γ-C
(sp3)–H arylation of aliphatic amines promoted by palladium–glyoxylic acid cooperative …

Methods that enable the practical and selective functionalization of traditionally unreactive
aliphatic C–H bonds have synthetic applications in fields ranging from drug discovery to …

Nitrogen heterocycles are of great medicinal importance, and the construction of nitrogen
heterocyclic scaffolds has been one of the focuses in synthetic organic chemistry. Recently …

The Pd (II)/sulfoxide-2-hydroxypyridine catalytic system shows promising activity in C–H
activation chemistry. In this study, we showcase how this catalytic system solves the problem …

An easily synthesized and accessible N, O‐bidentate auxiliary has been developed for
selective C H activation under palladium catalysis. The novel auxiliary showed its first …

Among the transition metals, copper-based catalyst systems enable the widest range of N-
containing reagents in C–H amination to allow for the direct incorporation of versatile N …

The metal-catalyzed “cascade C–H activation/annulation” is a highly promising approach to
the construction of aromatic and heteroaromatic compounds. In this context, Pd-complexes …

An efficient and convenient method enabling direct amination of unactivated methylene C
(sp3)–H bonds to form C–N bonds with azodiformates as amino source is described. This …