The oxidative activation of alkyl C–H bonds vs arene C–H bonds with Pd (OAc) 2 has been
found to be generalizable to a number of nucleophilic substrates, allowing the formation of a …

Carbon–nitrogen bond formation from inert C–H bonds is an ideal organic transformation
and a highly desirable method for the synthesis of N-containing molecules due to its high …

Metal-catalyzed cross-coupling reactions are among the most important transformations in
organic synthesis. However, the use of C–H activation for sp2 C–N bond formation remains …

PdII‐catalyzed intermolecular amination of unactivated C (sp3) H bonds has been
successfully developed for the first time. This method provides a new way to achieve the …

The palladium‐catalyzed coupling of amines with aryl halides or aryl alcohol derivatives,
commonly dubbed Buchwald–Hartwig amination, has matured from a synthetic laboratory …

A catalytic intermolecular amination of nonactivated tertiary C (sp3)–H bonds (BDE of 96
kcal· mol–1) is reported for substrates displaying an activated benzylic site (BDE of 85 kcal …

Conspectus α-Amino acids (αAA) are one of the most useful chiral building blocks for
synthesis. There are numerous general strategies that have commonly been used for αAA …

Conspectus The introduction of N-containing moieties into feedstock molecules to build
nitrogenated functional molecules has always been widely studied by the organic chemistry …

Conspectus The functionalization of unactivated carbon–hydrogen bonds is a transformative
strategy for the rapid construction of molecular complexity given the ubiquitous presence of …

Directed C–H functionalization is a powerful means to functionalize otherwise unreactive C–
H bonds, for which aminoquinoline amides provide a powerful and frequently used directing …