Site-selective functionalizations of C–H bonds are often achieved with a directing group that
leads to five-or six-membered metallacyclic intermediates. Analogous reactions that occur …

The alkylation of unactivated β‐methylene C (sp3) H bonds of α‐amino acid substrates
with a broad range of alkyl iodides using Pd (OAc) 2 as the catalyst is described. The …

A new synthetic approach toward direct C–N bond formation through sp3 C–H activation has
been developed under metal-free conditions. Both primary and secondary benzylic C–H …

Due to the low intrinsic acidity of amines, palladium-catalyzed C–N cross-coupling has been
plagued continuously by the necessity to employ strong, inorganic, or insoluble bases. To …

We have developed a Pd (II)-catalyzed oxidative tandem aminoalkylation via divergent C
(sp3)–H functionalization, affording three-and five-membered-ring fused indolines in good …

Pd (II)-catalyzed C–H bond functionalizations that proceed under ambient conditions are a
pivotal part of the future of chemical synthesis. Herein, an amine directed Pd (II)-catalyzed C …

Allylamines are important building blocks in the synthesis of bioactive compounds. The
direct coupling of allylic C− H bonds and commonly available amines is a major synthetic …

Homogeneous transition-metal-catalyzed reactions are indispensable to all facets of modern
chemical synthesis. It is thus difficult to imagine that for much of the early 20th century, the …

Finding optimal reaction conditions is usually complex, requires many experiments, and is
therefore demanding in terms of human, financial, and environmental resources. This work …

Over the past decades, organic chemists have focussed on developing new approaches to
directed C–H functionalisations, where the site selectivity is steered by the presence of a …