Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by alveolar
epithelial cell injury, accumulation of fibroblasts/myofibroblasts and deposition of …

Background Idiopathic pulmonary fibrosis (IPF) is characterised by the aberrant epithelial to
mesenchymal transition (EMT) and myofibroblast accumulation. Sphingosine-1-phosphate …

Idiopathic pulmonary fibrosis (IPF) is a disease that causes scarring and fibrotic
transformation of the lung parenchyma, resulting in the progressive loss of respiratory …

Sphingolipids comprise a class of bioactive lipids that are involved in a variety of
pathophysiologic processes, including cell death and survival. Ceramide and sphingosine-1 …

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease,
wherein transforming growth factor β (TGF-β) and sphingosine-1-phosphate (S1P) …

Introduction Idiopathic pulmonary fibrosis (IPF) is characterised by accumulation of
fibroblasts and myofibroblasts and deposition of extracellular matrix proteins. Sphingosine-1 …

Transforming growth factor β (TGF-β) contributes to the progression of pulmonary fibrosis
through up-regulation of α–smooth muscle actin (α–SMA) as lung myofibroblast …

Abstract Sphingosine-1-phosphate (S1P), a simple, bioactive sphingolipid metabolite, plays
a key role, both intracellularly and extracellularly, in various cellular processes such as …

Sphingolipids are a diverse class of signaling molecules implicated in many important
aspects of cellular biology, including growth, differentiation, apoptosis, and autophagy …

Aberrant wound healing responses to lung injury are believed to contribute to fibrotic lung
diseases, such as idiopathic pulmonary fibrosis (IPF). The lysophospholipids …