Alzheimer disease and oxidative stress

G Perry, AD Cash, MA Smith - BioMed Research International, 2002 - Wiley Online Library
Research in Alzheimer disease has recently demonstrated compelling evidence on the
importance of oxidative processes in its pathogenesis. Cellular changes show that oxidative …

Oxidative stress, antioxidants, and Alzheimer disease

CA Rottkamp, A Nunomura, AK Raina… - Alzheimer Disease & …, 2000 - journals.lww.com
Recent evidence in the field of Alzheimer disease research has highlighted the importance
of oxidative processes in its pathogenesis. Examination of cellular changes shows that …

[HTML][HTML] Oxidative stress in Alzheimer's disease

MA Smith, CA Rottkamp, A Nunomura, AK Raina… - … et Biophysica Acta (BBA …, 2000 - Elsevier
Oxidative balance is emerging as an important issue in understanding the pathogenesis of
Alzheimer's disease. Examination of Alzheimer's disease brain has demonstrated a great …

Reactive oxygen species mediate cellular damage in Alzheimer disease

G Perry, RJ Castellani, K Hirai… - Journal of Alzheimer's …, 1998 - content.iospress.com
The two most striking features of Alzheimer disease are (i) the multitude of abnormalities
affecting essentially every system and (ii) the strict age dependence. Recent work suggests …

Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species

G Casadesus, MA Smith, X Zhu, G Aliev… - Journal of …, 2004 - content.iospress.com
Free radical formation, abnormalities in iron and copper distribution, and metal-catalyzed
oxidation have all been noted in Alzheimer disease and are thought to play an important …

Oxidative stress in Alzheimer's disease

Z Chen, C Zhong - Neuroscience bulletin, 2014 - Springer
Oxidative stress plays a significant role in the pathogenesis of Alzheimer's disease (AD), a
devastating disease of the elderly. The brain is more vulnerable than other organs to …

Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms

R Von Bernhardi, J Eugenín - Antioxidants & redox signaling, 2012 - liebertpub.com
Alzheimer's disease (AD) is the most common cause of dementia and a progressive
neurodegeneration that appears to result from multiple pathogenic mechanisms (including …

Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease

R Bai, J Guo, XY Ye, Y Xie, T Xie - Ageing research reviews, 2022 - Elsevier
As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …

Oxidative stress in Alzheimer's disease: implications for prevention and therapy

C Behl - Alzheimer's Disease: Cellular and Molecular Aspects of …, 2005 - Springer
Oxidative stress is a marker of neurodegeneration and has been recently shown to be also
involved in the early stages of the pathogenesis of various neurodegenerative disorders. In …

Alzheimer disease and the role of free radicals in the pathogenesis of the disease

G Perry, PI Moreira, MS Santos… - CNS & Neurological …, 2008 - ingentaconnect.com
Oxidative stress occurs early in the progression of Alzheimer disease, significantly before
the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. All …