Multiple lines of evidence demonstrate that oxidative stress is an early event in Alzheimer's
disease (AD), occurring prior to cytopathology, and therefore may play a key pathogenic role …

Alzheimer's disease (AD) is an insidious and progressive neurodegenerative disorder that
affects millions of people worldwide. Although the pathogenesis remains obscure, there are …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a deadly
outcome. AD is the leading cause of senile dementia and although the pathogenesis of this …

Oxidative stress is known to play an important role in the pathogenesis of a number of
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …

This chapter reviews transition metal ion dysregulation and oxidative stress in the
pathogenesis of Alzheimer's disease. It focuses on the roles of metal ions in …

Considerable evidence is mounting that dyshomeostasis of the redox‐active biometals, Cu
and Fe, and oxidative stress contribute to the neuropathology of Alzheimer's disease (AD) …

Metal-catalyzed hydroxyl radicals are potent mediators of cellular injury, affecting every
category of macromolecule, and are central to the oxidative injury hypothesis of Alzheimer …

Alzheimer's disease is a neurodegenerative disorder comprising multisystem atrophies
probably caused by multifactorial processes. The disease is characterized by typical …

ANTIOXIDANTS & REDOX SIGNALING Volume 5, Number 5, 2003© Mary Ann Liebert, Inc.
free radicals (4, 13, 40). Iron-and copper-induced free radical damage may play a …

Historically, efforts to understand oxidative status have focused on the concept of oxidative
stress, ie, the breaching of oxidant defenses with consequent detriment. By this definition …