Thoroughly revised and updated, this Third Edition encompasses the most recent advances
in molecular and cellular research and describes the newest therapeutic modalities for type …

The Pima Indians of Arizona are known in history for the fierce battles they fought against
neighboring Apache Indians. Now, however, remnants of the two tribes live in harmony amid …

OBJECTIVE: This article examines the foundation of β-cell failure in type 2 diabetes (T2D)
and suggests areas for future research on the underlying mechanisms that may lead to …

Abstract Context: The Centers for Disease Control and Prevention estimates that there are
approximately 79,000,000 individuals in the United States with prediabetes [impaired …

With the conceptual advance about four decades ago that type 1 diabetes represents an
autoimmune disease, hope arose that immune-based therapies would soon emerge to …

Type 2 Diabetes Mellitus (T2DM) is characterized by chronically elevated blood glucose
(hyperglycemia) and elevated blood insulin (hyperinsulinemia). When the blood glucose …

Type 2 diabetes (T2D) has attained the status of a global pandemic, spreading from affluent
industrialized nations to the emerging economies of Asia, Latin America, and Africa. There is …

Type 1 diabetes results from the autoimmune destruction of insulin-producing β cells in the
pancreas. Genetic and, as yet undefined, environmental factors act together to precipitate …

β-cell dysfunction and insulin resistance are two central, interrelated defects in the
pathophysiology of type 2 diabetes. By the time a patient's hyperglycemia is recognized …

Diabetes is among the biggest of the 21st-century global health challenges. In the US and
other high-income countries, thanks to investments in science, dedication to implementing …