Introduction Many pediatric urology conditions affect putatively normal tissues or appear too
commonly to be based solely on specific DNA mutations. Understanding epigenetic …

Congenital obstructive malformations of the ureter are amongst the most common human
birth defects. To date, the etiology of these diseases has remained largely unexplored …

Background: Partial bladder outlet obstruction (PBO) is a widespread cause of urinary
dysfunction and patient discomfort, resulting in immense health care costs. Previously, we …

The bladder exstrophy-epispadias complex (BEEC) represents a spectrum of urological
abnormalities where part, or all, of the distal urinary tract fails to close during development …

PURPOSE: We characterize the urothelium from patients with classic bladder exstrophy-
epispadias complex for the expression of proteins associated with urothelial differentiation …

Congenital ureter anomalies, including hydroureter, affect up to 1% of the newborn children.
Despite the prevalence of these developmental abnormalities in young children, the …

The urinary tract comprises the renal pelvis, the ureter, the urinary bladder, and the urethra.
The tract acts as a functional unit, first propelling urine from the kidney to the bladder, then …

PURPOSE: To better understand the pathobiology of human congenital bladder
abnormalities and disorders associated with dedifferentiation, such as bladder cancer, we …

OBJECTIVE To compare the genetic profiles of 'healthy'bladder smooth muscle cells (SMCs)
and exstrophic SMCs (ESMCs) to identify genes that are over‐and under‐expressed in …

Urinary bladder malfunction and disorders are caused by congenital diseases, trauma,
inflammation, radiation, and nerve injuries. Loss of normal bladder function results in urinary …