The presence of cytosolic double-stranded DNA molecules can trigger multiple innate
immune signalling pathways which converge on the activation of an ER-resident innate …

Viral infection activates transcription factors NF-κB and IRF3, which collaborate to induce
type I interferons (IFNs) and elicit innate antiviral response. MITA (also known as STING) has …

Nucleic acids from bacteria or viruses induce potent immune responses in infected cells,,–.
The detection of pathogen-derived nucleic acids is a central strategy by which the host …

Phagocytes cope with the threat of living bacteria via detection of vita-PAMPs, a specific
class of pathogen-associated molecular patterns (PAMPs) that denotes microbial viability …

Stimulator of IFN genes (STING) is an adaptor that functions downstream of retinoic acid–
inducible gene I (RIG-I) in mammalian cells; however, RIG-I is absent in chickens. We …

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Background The study of autoinflammatory diseases has uncovered mechanisms
underlying cytokine dysregulation and inflammation. Methods We analyzed the DNA of an …

STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown
mechanisms. Here, we found that these mutants induce chronic activation of ER stress and …

DNA sensing and timely activation of interferon (IFN)-mediated innate immunity are crucial
for the defense against DNA virus infections and the clearance of abnormal cells. However …

The nucleic acids of Mycobacterium tuberculosis can be detected by intracellular DNA
sensors, such as cyclic GMP-AMP synthase and absent in melanoma 2 (AIM2), which results …