Abstract Small Rho GTPases are key regulators of the cytoskeleton in a great variety of cells.
Rho function mediates morphological changes as well as locomotor activity. Using astrocyte …

Formation of neurites and their differentiation into axons and dendrites requires precisely
controlled changes in the cytoskeleton. While small GTPases of the Rho family appear to be …

Inhibition of the small GTPase Rho or of its downstream target Rho-associated kinase
(ROCK) has been shown to promote axon regeneration and to improve functional recovery …

Successful regeneration in the central nervous system crucially depends on the adequate
environment. Microglia as brain immune‐competent cells importantly contribute to this task …

Rho family GTPases have been assigned important roles in the formation of actin-based
morphologies in nonneuronal cells. Here we show that microinjection of Cdc42Hs and Rac1 …

Background Blockade of the small GTPase Rho (ras homology protein) or of its downstream
target Rho-associated kinase has been shown to promote axon regeneration in vitro and in …

Rho GTPases are molecular switches that modulate multiple intracellular signaling
processes by means of various effector proteins. As a result, Rho GTPase activities are …

The Rho family of small GTPases act as intracellular molecular switches that transduce
signals from extracellular stimuli to the actin cytoskeleton and the nucleus. Recent evidence …

Rho small GTPases regulate a variety of cellular signaling pathways involved in cell growth
and transformation. In this study, we examined potential roles for Rho in adhesion …

Publisher Summary This chapter discusses the inactivation of intracellular Rho to stimulate
axon growth and regeneration. In tissue culture, inactivation of the Rho signaling pathway is …