Extensions to pedigree analysis. IV. Covariance components models for multivariate traits
Often more than one quantitative trait is measured on each person in a set of pedigrees. The
present paper suggests a class of covariance components models that will allow …
present paper suggests a class of covariance components models that will allow …
Predicting long-term response to selection
JP REEVE - Genetics Research, 2000 - cambridge.org
Lande's equation for predicting the response of trait means to a shift in optimal trait values is
tested using a stochastic simulation model. The simulated population is finite, and each …
tested using a stochastic simulation model. The simulated population is finite, and each …
QU-GENE: a simulation platform for quantitative analysis of genetic models.
DW Podlich, M Cooper - Bioinformatics (Oxford, England), 1998 - academic.oup.com
MOTIVATION: Classical quantitative genetics theory makes a number of simplifying
assumptions in order to develop mathematical expressions that describe the mean and …
assumptions in order to develop mathematical expressions that describe the mean and …
Multivariate mutation-selection balance with constrained pleiotropic effects.
GP Wagner - Genetics, 1989 - academic.oup.com
A multivariate quantitative genetic model is analyzed that is based on the assumption that
the genetic variation at a locus j primarily influences an underlying physiological variable yj …
the genetic variation at a locus j primarily influences an underlying physiological variable yj …
Markov chain Monte Carlo segregation and linkage analysis for oligogenic models
SC Heath - The American Journal of Human Genetics, 1997 - cell.com
A new method for segregation and linkage analysis, with pedigree data, is described.
Reversible jump Markov chain Monte Carlo methods are used to implement a sampling …
Reversible jump Markov chain Monte Carlo methods are used to implement a sampling …
The coalescent process in models with selection
NL Kaplan, T Darden, RR Hudson - Genetics, 1988 - academic.oup.com
Statistical properties of the process describing the genealogical history of a random sample
of genes are obtained for a class of population genetics models with selection. For models …
of genes are obtained for a class of population genetics models with selection. For models …
[图书][B] Genetic data analysis. Methods for discrete population genetic data.
BS Weir - 1990 - cabidigitallibrary.org
This book describes, in detail, statistical methods used in the analysis of population genetic
data of a discrete (enumeration) nature, such as genotype frequencies. It is not concerned …
data of a discrete (enumeration) nature, such as genotype frequencies. It is not concerned …
Spatial patterns in the distributions of polygenic characters
M Slatkin - Journal of Theoretical Biology, 1978 - Elsevier
The spatial patterns in the mean and variance of a quantitative character that result from the
interaction of spatially varying, optimizing selection and gene flow are considered. The …
interaction of spatially varying, optimizing selection and gene flow are considered. The …
The genetic covariance between characters maintained by pleiotropic mutations
R Lande - Genetics, 1980 - academic.oup.com
ABSTRACT A statistical genetic model of a multivariate phenotype is derived to investigate
the covariation of pleiotropic mutations with additive effects under the combined action of …
the covariation of pleiotropic mutations with additive effects under the combined action of …
Multifactorial genetic models for quantitative traits in humans
CR Boyle, RC Elston - Biometrics, 1979 - JSTOR
Quantitative traits measured in human families can be analyzed to partition the total
population variance into genetic and environmental components, or to elucidate the genetic …
population variance into genetic and environmental components, or to elucidate the genetic …