Discussions about evolutionary change in developmental processes or morphological
structures are predicated on specific quantitative genetic models whose parameters predict …

Additive genetic variances and covariances of quantitative characters are necessary to
predict the evolutionary response of the mean phenotype vector in a population to natural or …

The evolution of quantitative characters depends on the frequencies of the alleles involved,
yet these frequencies cannot usually be measured. Previous groups have proposed an …

Over the last ten years the introduction of computer intensive statistical methods has opened
new horizons concerning the probability models that can be fitted to genetic data, the scale …

The Wright–Fisher model provides an elegant mathematical framework for understanding
allele frequency data. In particular, the model can be used to infer the demographic history …

The maintenance of polygenic variability by a balance between mutation and stabilizing
selection has been analysed using two approximations: the 'Gaussian'and the 'house of …

Methods for inference and interpretation of evolutionary quantitative genetic parameters,
and for prediction of the response to selection, are best developed for traits with normal …

In human quantitative genetics, computational complexity restricts the current methods for
estimation of mixed models that include major gene effects to data on small pedigrees …

The maintenance of polygenic variation through a balance between mutation and stabilizing
selection can be approximated in two ways. In the 'Gaussian'approximation, a normal …

The simple Markovian structures of dependence, defined previously for continuous traits, are
extended here to familial disease and other binary traits through the use of the logistic …