We describe a variance-components method for multipoint linkage analysis that allows joint
consideration of a discrete trait and a correlated continuous biological marker (eg, a disease …

Numerous Bayesian methods of phenotype prediction and genomic breeding value
estimation based on multilocus association models have been proposed. Computationally …

The following models are considered for the genetic determination of quantitative traits:
segregation at one locus, at two linked loci, at any number of equal and additive unlinked …

The Pedigree Analysis Package (PAP) comprises a set of FORTRAN 90 programs for
computing likelihoods [Elston & Stewart 1971] or simulating phenotypes on pedigree …

Contemporary models of multifactorial inheritance are described and justified from the
perspective of their intended use in genetic epidemiology and their developmental …

Semiparametric procedures for prediction of total genetic value for quantitative traits, which
make use of phenotypic and genomic data simultaneously, are presented. The methods …

Background In the genetic analysis of binary traits with one observation per animal, animal
threshold models frequently give biased heritability estimates. In some cases, this problem …

In human linkage analysis, many statistical problems without analytical solution could be
solved by ad hoc Monte Carlo procedures were efficient computer-simulation methods …

To understand fully the process of evolution of quantitative traits it is necessary to be able to
estimate the genetic correlation and its associated standard error. At present, estimation …

A quantitative genetic model relates the genotypic value of an individual to the alleles at the
loci that contribute to the variation in a population in terms of additive, dominance, and …