Background The genome of SARS-CoV-2 is susceptible to mutations during viral replication
due to the errors generated by RNA-dependent RNA polymerases. These mutations enable …

We introduce VERSO, a two-step framework for the characterization of viral evolution from
sequencing data of viral genomes, which improves over phylogenomic approaches for …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic surveillance has
been vital in understanding the spread of coronavirus disease 2019 (COVID-19), the …

Background Genomic surveillance of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is the only approach to rapidly monitor and tackle emerging variants of …

Analysis of SARS-CoV-2 genetic diversity within infected hosts can provide insight into the
generation and spread of new viral variants and may enable high resolution inference of …

The human pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
responsible for the major pandemic of the twenty-first century. We analyzed more than 4700 …

Since the beginning of the SARS-CoV-2 pandemic, there has been international concern
about the emergence of virus variants with mutations that increase transmissibility, enhance …

SARS-CoV-2 whole genome sequencing has played an important role in documenting the
emergence of polymorphisms in the viral genome and its continuing evolution during the …

Summary Objectives The SARS-CoV-2 pandemic and large-scale genomic surveillance
provided an exceptional opportunity to analyze mutations that appeared over three years in …

Genetic analysis of intra-host viral populations provides unique insight into pre-emergent
mutations that may contribute to the genotype of future variants. Clinical samples positive for …