The antinociceptive effect of dipyrone, a nonsteroidal anti-inflammatory drug, was studied in
a series of experiments employing tail-flick and hot-plate models and the abdominal …

Dipyrone is classified as a nonsteroidal anti-inflammatory drug. It has analgesic, antipyretic
and anti-inflammatory properties and exerts its analgesic effect via both peripheral and …

Dipyrone injected intraperitoneally (ip) or subplantarly into the mouse paw caused dose-
related antinociception against the early and the late phases of formalin-induced licking …

Electrophysiological experiments in anesthetized cats and rats were performed in order to
study the effects of dipyrone on single afferent fibers from the knee joint and on spinal cord …

The antinociceptive effect of orphenadrine citrate, a muscle relaxant, was investigated in
mice. Four different pain tests were selected to involve different noxious stimuli. Clear …

Recent studies suggest that non-steroidal anti-inflammatory drugs have central sites of
action which contribute to their analgesic efficacy. In the present study microinjections of the …

Abstract A novel compound, FR64822 (N-(4-pyridylcarbamoyl) amino 1, 2, 3, 6,-
tetrahydropyridine), displays antinociceptive activities in a variety of assays with mice and …

The antinociceptive effect of dipyrone is partly due to its action upon pain-related central
nervous system structures. Despite intensive research, the precise mechanisms mediating …

This study aimed to investigate further the mechanisms involved in the antinociception
caused by dipyrone, given by intraperitoneal (ip) or intrathecal (it) routes. The intraperitoneal …

The objective of this study was to investigate spinal and supraspinal antinociceptive effects
of a new synthetic compound,(±)-cis-(6-ethyl-tetrahydropyran-2-yl)-formic acid …