New experimental data linking secondhand smoke exposure to lung cancer in nonsmokers

SI Kim, JI Yoon, S Tommasi, A Besaratinia - The FASEB Journal, 2012 - escholarship.org
Secondhand smoke (SHS) exposure is a known risk factor for lung cancer development in
lifelong nonsmokers; however, the mechanistic involvement of SHS in the genesis of this …

Whole body exposure of mice to secondhand smoke induces dose-dependent and persistent promutagenic DNA adducts in the lung

SI Kim, VM Arlt, JI Yoon, KJ Cole, GP Pfeifer… - Mutation Research …, 2011 - Elsevier
Secondhand smoke (SHS) exposure is a known risk factor for lung cancer in lifelong
nonsmokers. However, the underlying mechanism of action of SHS in lung carcinogenesis …

Expression of epigenetic modifiers is not significantly altered by exposure to secondhand smoke

S Tommasi, A Zheng, A Besaratinia - Lung Cancer, 2015 - Elsevier
Objectives Secondhand smoke (SHS) is a major risk factor for lung cancer in nonsmokers.
DNA damage-derived mutagenicity is a well-established mechanism of SHS …

Exposure of mice to secondhand smoke elicits both transient and long‐lasting transcriptional changes in cancer‐related functional networks

S Tommasi, A Zheng… - International journal of …, 2015 - Wiley Online Library
Secondhand smoke (SHS) has long been linked to lung cancer and other diseases in
nonsmokers. Yet, the underlying mechanisms of SHS carcinogenicity in nonsmokers remain …

Passive Smoking–Induced Mutagenesis as a Promoter of Lung Carcinogenesis

A Mochizuki, K Shiraishi, T Honda… - Journal of Thoracic …, 2024 - Elsevier
Abstract Introduction The International Agency for Research on Cancer has classified
passive smoking (PS) or secondhand smoke exposure as a group 1 carcinogen linked to …

Induction and modulation of lung tumors: genomic and transcriptional alterations in cigarette smoke-exposed mice

S De Flora, A Izzotti, F D'Agostini… - Experimental lung …, 2004 - Taylor & Francis
Cigarette smoke plays a major role in the epidemiology of lung cancer, and smoke
components have extensively been investigated in carcinogenicity and chemoprevention …

Molecular damage and lung tumors in cigarette smoke–exposed mice

A Izzotti, A Pulliero - Annals of the New York Academy of …, 2015 - Wiley Online Library
Cigarette smoke (CS) induces lung cancer through a multistep process that is now being
depicted by molecular analyses. During the early phase (weeks), DNA damage occurs in …

Molecular Alterations and Lung Tumors in p53 Mutant Mice Exposed to Cigarette Smoke

S De Flora, RM Balansky, F D'Agostini, A Izzotti… - Cancer research, 2003 - AACR
Mutations and deletions in p53 are the most common genetic lesions in human cancer, and
an extraordinarily high incidence of lung cancer occurs in smokers suffering from Li …

Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice

B Hang, Y Wang, Y Huang, P Wang… - Clinical …, 2018 - portlandpress.com
Exposure to thirdhand smoke (THS) is a recently described health concern that arises in
many indoor environments. However, the carcinogenic potential of THS, a critical …

Thirdhand smoke exposure causes replication stress and impaired transcription in human lung cells

AH Sarker, KS Trego, W Zhang… - Environmental and …, 2020 - Wiley Online Library
Thirdhand cigarette smoke (THS) is a newly described toxin that lingers in the indoor
environment long after cigarettes have been extinguished. Emerging results from both …