Piperacillin in combination with tazobactam, a β-lactamase inhibitor, is a commonly used
intravenous antibiotic for the empirical treatment of infection in intensive care patients …

This was a prospective study to determine if pharmacokinetic/pharmacodynamic (PK/PD)-
based antibiotic dosing software aids in achieving concentration targets in critically ill …

Background: Sustained low-efficiency dialysis (SLED), is increasingly being used in
intensive care units (ICUs) but studies informing drug dosing for such patients is lacking …

Standard doses of piperacillin/tazobactam (9–13.5 g over 24 h) administered by continuous
infusion (CI) routinely provide serum concentrations in excess of the susceptibility …

This prospective pharmacokinetic study aimed to compare the clearance of piperacillin-
tazobactam administered as a 24-h continuous infusion between continuous venovenous …

Background Antibiotic exposure in intensive care patients with sepsis is frequently
inadequate and is associated with poorer outcomes. Antibiotic dosing is challenging in the …

The objective of this study was to evaluate the steady-state pharmacokinetics and
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …

Since the bactericidal effects of β-lactam antibiotics are time dependent, the optimum
strategy for their administration could be continuous infusion. In this prospective …

Therapeutic drug monitoring (TDM) of antibiotics is recommended and increasingly used in
critically ill patients to optimize target attainment and account for interpatient …

Introduction Antibiotics are commonly prescribed in critical care, and given the large
variability of pharmacokinetic (PK) parameters in these patients, drug PK frequently varies …