Methods: Blood samples (2–4 per child) were collected from 13 children ages 9 months to 6
years admitted to the pediatric intensive care unit who were receiving standard piperacillin …

Antimicrobial dosing in the intensive care unit (ICU) can be problematic due to various
challenges including unique physiological changes observed in critically ill patients and the …

Objective: To discuss the altered pharmacokinetic properties of selected antibiotics in
critically ill patients and to develop basic dose adjustment principles for this patient …

The judicious use of existing antibiotics is essential for preserving their activity against
infections. In the era of multi-drug resistance, this is of particular importance in clinical areas …

Objective: Obesity and critical illness modify pharmacokinetics of antibiotics, but piperacillin-
tazobactam continuous IV infusion pharmacokinetics has been poorly studied in obese …

Study Objective To evaluate the steady‐state pharmacokinetic and pharmacodynamic
parameters of piperacillin in morbidly obese, surgical intensive care patients. Design Open …

Continuous infusion (CI) piperacillin/tazobactam is frequently used to treat infections in very
elderly patients. This study aimed to conduct a population pharmacokinetic analysis of CI …

Objective: To perform a qualitative systematic review of the evidence comparing traditional
strategies against prolonged intermittent or continuous infusion strategies for piperacillin …

Introduction: Emerging studies suggest that antibiotic pharmacokinetics (PK) are difficult to
predict in critically ill patients. The high intra-and inter-patient PK variability makes it …

Objectives: We investigated the population pharmacokinetics and pharmacodynamics of
piperacillin and tazobactam in hospitalized patients. Patients and methods: A multicentre …