Hypertriglyceridemia in the genomic era: a new paradigm

GF Lewis, C Xiao, RA Hegele - Endocrine reviews, 2015 - academic.oup.com
Hypertriglyceridemia (HTG) is a highly prevalent condition that is associated with increased
cardiovascular disease risk. HTG may arise as a result of defective metabolism of …

The genetic basis of hypertriglyceridemia

GD Carrasquilla, MR Christiansen… - Current atherosclerosis …, 2021 - Springer
Abstract Purpose of Review Hypertriglyceridemia is a common dyslipidemia associated with
an increased risk of cardiovascular disease and pancreatitis. Severe hypertriglyceridemia …

Genetic bases of hypertriglyceridemic phenotypes

CT Johansen, RA Hegele - Current opinion in lipidology, 2011 - journals.lww.com
Compared to other complex traits, genetic variants account for a high proportion of HTG
diagnoses. By tallying the number of HTG risk alleles, it is possible to discriminate between …

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management

RA Hegele, HN Ginsberg, MJ Chapman… - The lancet Diabetes & …, 2014 - thelancet.com
Plasma triglyceride concentration is a biomarker for circulating triglyceride-rich lipoproteins
and their metabolic remnants. Common mild-to-moderate hypertriglyceridaemia is typically …

Genetics of hypertriglyceridemia

JS Dron, RA Hegele - Frontiers in endocrinology, 2020 - frontiersin.org
Hypertriglyceridemia, a commonly encountered phenotype in cardiovascular and metabolic
clinics, is surprisingly complex. A range of genetic variants, from single-nucleotide variants …

Hypertriglyceridemia

A Brahm, RA Hegele - Nutrients, 2013 - mdpi.com
Hypertriglyceridemia (HTG) is commonly encountered in lipid and cardiology clinics. Severe
HTG warrants treatment because of the associated increased risk of acute pancreatitis …

[HTML][HTML] Severe hypertriglyceridemia is primarily polygenic

JS Dron, J Wang, H Cao, AD McIntyre… - Journal of clinical …, 2019 - Elsevier
Background Hypertriglyceridemia (HTG) is a complex trait defined by elevated plasma
triglyceride levels. Genetic determinants of HTG have so far been examined in a piecemeal …

Hypertriglyceridemia: phenomics and genomics

RA Hegele, RL Pollex - Molecular and cellular biochemistry, 2009 - Springer
Hypertriglyceridemia is a common complex metabolic trait that is associated with increased
atherosclerosis risk, presence of the metabolic syndrome and, with extreme elevation …

Hypertriglyceridemia—causes, significance, and approaches to therapy

LS Santos-Baez, HN Ginsberg - Frontiers in Endocrinology, 2020 - frontiersin.org
Hypertriglyceridemia (HTG) is a common metabolic disorder with both genetic and lifestyle
factors playing significant roles in its pathophysiology. HTG poses a risk for the development …

Allelic and phenotypic spectrum of plasma triglycerides

CT Johansen, RA Hegele - Biochimica et Biophysica Acta (BBA)-Molecular …, 2012 - Elsevier
The genetic underpinnings of both normal and pathological variation in plasma triglyceride
(TG) concentration are relatively well understood compared to many other complex …