Osteoarthritis (OA) is a chronic musculoskeletal disorder characterized by an imbalance
between (synthesis) and catabolism (degradation) in altered homeostasis of articular …

The matrix metalloproteinases (MMPs) are a family of enzymes that collectively degrade all
components of the extracellular matrix. MMPs play crucial roles in normal physiologic …

Arthritic diseases cause enormous burdens in terms of pain, crippling, and disability.
Osteoarthritis (OA), the most common form of arthritis, is characterized by a slow progressive …

Classically, osteoarthritis (OA) is not considered an inflammatory arthropathy, because of the
presence of a small number of neutrophils in the synovial fluid and the absence of systemic …

Osteoarthritis (OA) is a complex disease whose pathogenesis includes the contribution of
biomechanical and metabolic factors which, altering the tissue homeostasis of articular …

OA is now well accepted as a low-grade inflammatory disease affecting the whole joint. In
addition to mechanical loading, inflammation (particularly synovitis), contributes significantly …

Primary osteoarthritis (OA) is a musculoskeletal disorder of unknown etiology. OA is
characterized by an imbalance between anabolism and catabolism in, and altered …

Osteoarthritis (OA) is a debilitating, progressive disease of diarthrodial joints associated with
aging. At the molecular level, OA is characterized by an imbalance between anabolic (ie …

Extensive degeneration of articular cartilage (AC) is a primary event in the pathogenesis of
osteoarthritis (OA) and other types of joint and bone inflammation. OA results in the loss of …

Objectives As more has become known of the pathophysiology of osteoarthritis (OA),
evidence that inflammation plays a critical role in its development and progression has …