Metalloproteinases such as the matrix metalloproteinases (MMPs) and disintegrin-
metalloproteinases with thrombospondin motifs (ADAMTSs) have been implicated in the …

Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …

Although osteoarthritis (OA) was historically referred to as the non-inflammatory arthritis, it is
now considered a condition involving persistent low-grade inflammation and activation of …

Osteoarthritis (OA) is a disease that predominantly, but not solely, affects the diarthrodial
joints and results from an interaction between a number of complex mechanical and …

The biological events associated with inflammation are intimately intertwined with the
musculoskeletal system. Inflammation plays a critical role in the healing process of all …

Metalloproteinases were first identified as collagen cleaving enzymes and are now
appreciated to play important roles in a wide variety of biological processes. The aberrant …

Objective To identify specific transcription factors that are activated in the cartilage tissue of
osteoarthritis (OA) patients and are involved in the expression of matrix metalloproteinase 1 …

Osteoarthritis (OA) is the most prevalent joint disease characterized by pain and
degenerative lesions of the cartilage, subchondral bone, and other joint tissues. The causes …

This review focuses on the recent advancements in the understanding of innate immunity in
the pathogenesis of osteoarthritis, particularly with attention to the roles of damage …

Key Points Osteoarthritis (OA) is one of the most chronic health disorders in the western
world and becomes particularly common with advanced age. The joints most commonly …