Several polymorphisms in genes that encode platelet components (receptors or enzymes),
or cytochrome P450 enzyme isoforms, involved in clopidogrel metabolism, have been …

Patients with lesser degrees of platelet inhibition in response to clopidogrel appear to be at
increased risk for recurrent ischemic events. Cytochrome P450 (CYP) polymorphisms have …

Background Previous studies have investigated the relationship between CYP2C19
polymorphism and clinical prognosis in coronary artery disease patients treated with …

Aims To perform a meta-analysis of the association between CYP2C19 loss-and gain-of-
function variants and cardiovascular outcomes and bleeding in patients with coronary artery …

Genetic variation in the cytochrome P450 2C19 (CYP2C19) gene has been documented
gradually as the determinant conversion and variability in the antiplatelet effect of …

Summary Background Cytochrome P450 2C19 (CYP2C19) is the principal enzyme
responsible for converting clopidogrel into its active metabolite, and common genetic …

Background: With the cytochrome P450 CYP2C19* 2 (* 2) allelic variant resulting in
complete loss of enzyme function and the CYP2C19* 17 (* 17) variant being linked to …

Aims Several studies have demonstrated that the mutant* 2 allele of the CYP2C19 681G> A
loss-of-function polymorphism is associated with diminished metabolization of clopidogrel …

Objective To evaluate the accumulated information from genetic association studies
investigating the impact of variants of the cytochrome P450 (CYP) 2C19 genotype on the …

Background Although East Asians carry the cytochrome P450 (CYP) 2C19* 2 allele more
frequently than do Caucasians, the impact of the CYP2C19* 2 allele on clopidogrel …