Extracellular nucleotides have been implicated in a number of physiological functions.
Nucleotides act on cell-surface receptors known as P2 receptors, of which several subtypes …

Although the effects of nucleotides in the cardiovascular system have been known for almost
70 years, it is only in the past few years that some of the P2 receptors at which they act have …

ARL66096, a potent inhibitor of ADP-induced platelet aggregation, blocks ADP-induced
inhibition of adenylate cyclase, but fails to inhibit ADP-mediated [Ca2+] i increases22 …

Nucleotides are emerging as an ubiquitous family of extracellular signaling molecules. It has
been known for many years that adenosine diphosphate is a potent platelet aggregating …

In addition to its key role in cellular metabolism where it acts as a ubiquitous enzyme
cofactor and as the key source of the cellular energy unique to phosphate bond formation …

The role of ATP as an extracellular signalling molecule is now well established and
evidence is accumulating that ATP and other nucleotides (ADP, UTP and UDP) play …

Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …

P2 receptors mediate the actions of the extracellular nucleotides ATP, ADP, UTP, and UDP,
regulating several physiologic responses including cardiac function, vascular tone, smooth …

The cDNA encoding a novel P 2 receptor was isolated from rat aortic smooth muscle cell
library and functionally characterized. The cloned P 2 receptor exhibits structural features …

The action of extracellular nucleotides, specifically the ability of adenine nucleotides to
induce coronary vasodilation and bradycardia, was first described more than 70 years ago …