HDL in sepsis–risk factor and therapeutic approach
EE Morin, L Guo, A Schwendeman, XA Li - Frontiers in pharmacology, 2015 - frontiersin.org
High-density lipoprotein (HDL) is a key component of circulating blood and plays essential
roles in regulation of vascular endothelial function and immunity. Clinical data demonstrate …
roles in regulation of vascular endothelial function and immunity. Clinical data demonstrate …
High-density lipoproteins during sepsis: from bench to bedside
S Tanaka, D Couret, A Tran-Dinh, J Duranteau… - Critical Care, 2020 - Springer
High-density lipoproteins (HDLs) represent a family of particle characterized by the
presence of apolipoprotein AI (apoA-I) and by their ability to transport cholesterol from …
presence of apolipoprotein AI (apoA-I) and by their ability to transport cholesterol from …
Replenishing HDL with synthetic HDL has multiple protective effects against sepsis in mice
Sepsis is a major health issue with mortality exceeding 30% and few treatment options. We
found that high-density lipoprotein cholesterol (HDL-C) abundance was reduced by 45% in …
found that high-density lipoprotein cholesterol (HDL-C) abundance was reduced by 45% in …
High density lipoprotein protects against polymicrobe-induced sepsis in mice
L Guo, J Ai, Z Zheng, DA Howatt, A Daugherty… - Journal of Biological …, 2013 - ASBMB
HDL has been considered to be a protective factor in sepsis; however, most contributing
studies were conducted using the endotoxic animal model, and evidence from clinically …
studies were conducted using the endotoxic animal model, and evidence from clinically …
Two‐year follow‐up of patients with septic shock presenting with low HDL: the effect upon acute kidney injury, death and estimated glomerular filtration rate
Background Sepsis is associated with decreased levels of high‐density lipoprotein (HDL)
cholesterol. HDL has anti‐inflammatory properties, and the use of Apo A‐I mimetic peptides …
cholesterol. HDL has anti‐inflammatory properties, and the use of Apo A‐I mimetic peptides …
High-density lipoproteins in sepsis and septic shock: metabolism, actions, and therapeutic applications
A Wu, CJ Hinds, C Thiemermann - Shock, 2004 - journals.lww.com
Sepsis and septic shock are important causes of morbidity and lethality in noncoronary
intensive care units. Circulating levels of high-density lipoproteins (HDLs) are reduced in …
intensive care units. Circulating levels of high-density lipoproteins (HDLs) are reduced in …
Lipoproteins in inflammation and sepsis. I. Basic science
O Murch, M Collin, CJ Hinds, C Thiemermann - Intensive care medicine, 2007 - Springer
Background High-density lipoproteins (HDL) have been shown to bind and neutralize
lipopolysaccharide (LPS) and are regarded as possible therapeutic agents for sepsis and …
lipopolysaccharide (LPS) and are regarded as possible therapeutic agents for sepsis and …
Impact of sepsis on high-density lipoprotein metabolism
AC Reisinger, M Schuller, H Sourij… - Frontiers in cell and …, 2022 - frontiersin.org
Background: High-density lipoproteins (HDL) are thought to play a protective role in sepsis
through several mechanisms, such as promotion of steroid synthesis, clearing bacterial …
through several mechanisms, such as promotion of steroid synthesis, clearing bacterial …
Beneficial effects of recombinant CER-001 high-density lipoprotein infusion in sepsis: results from a bench to bedside translational research project
Background Sepsis is characterized by a dysregulated immune response and metabolic
alterations, including decreased high-density lipoprotein cholesterol (HDL-C) levels. HDL …
alterations, including decreased high-density lipoprotein cholesterol (HDL-C) levels. HDL …
Anti-inflammatory mechanisms of apolipoprotein AI mimetic peptide in acute respiratory distress syndrome secondary to sepsis
OF Sharifov, X Xu, A Gaggar, WE Grizzle, VK Mishra… - PLoS …, 2013 - journals.plos.org
Acute respiratory distress syndrome (ARDS) due to sepsis has a high mortality rate with
limited treatment options. High density lipoprotein (HDL) exerts innate protective effects in …
limited treatment options. High density lipoprotein (HDL) exerts innate protective effects in …