The role of Interleukin (IL)-6 in the pathogenesis of joint and systemic inflammation in
rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis (s-JIA) has been clearly …

Interleukin 6 (IL6) is a pleiotropic cytokine with a wide range of biological activities. IL6
transgene into mice gives rise to the abnormalities such as hyper-γ-globulinaemia …

Abstract Introduction Interleukin (IL)-27 is a novel member of the IL-6/IL-12 family cytokines
that are produced early by antigen-presenting cells in T helper (Th) 1-mediated …

The IL-1 family comprises two anti-inflammatory cytokines (IL-37, IL-38), two receptor
antagonists (IL-1ra, IL-36ra), and seven ligand agonists (IL-1α, IL-1β, IL-33, IL-36α, IL-36β …

Abstract Interleukin-17 (IL-17) is a T cell cytokine spontaneously produced by cultures of
rheumatoid arthritis (RA) synovial membranes. High levels have been detected in the …

Background Interleukin (IL)-36α is a recently described member of the IL-1 cytokine family
with pro-inflammatory and clearly pathogenic properties in psoriasis. Objective To determine …

Objective: Interleukin (IL) 23, composed of a p19 and a p40 subunit, is suggested to play key
roles in rheumatoid arthritis (RA), dependent on the promotion and proliferation of IL17 …

Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …

The prominence of T cells and monocyte/macrophages in rheumatoid synovium suggests T
cells may localize and amplify the effector functions of monocyte/macrophages in …

Although the role of IL-7 and IL-7R has been implicated in the pathogenesis of rheumatoid
arthritis (RA), the majority of the studies have focused on the effect of IL-7/IL-7R in T cell …