Cytokines are the key mediators of inflammation in the course of autoimmune arthritis and
other immune-mediated diseases. Uncontrolled production of the pro-inflammatory …

The IL-1 family of cytokines encompasses eleven proteins that each share a similar-barrel
structure and bind to Ig-like receptors. Some of the IL-1-like cytokines have been well …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the
accumulation of inflammatory cells into the synovium and the destruction of joints. Cytokines …

The activity of each member of the IL-1 family of ligands is mediated by its own receptor.
Each ligand binds specifically to the extracellular “ligand binding chain” containing three Ig …

The biology behind interleukin-6 targeted interventions : Current Opinion in Rheumatology The
biology behind interleukin-6 targeted interventions : Current Opinion in Rheumatology Log in or …

The incidence and diversity of chronic inflammatory diseases is increasing worldwide.
However, the complexity of clinical symptoms has made it difficult to develop therapies that …

Interleukin‐1 receptor family members (ILR s) and Toll‐Like Receptors (TLR s) are key
players in immunity and inflammation and are tightly regulated at different levels. Most cell …

Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family
includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL …

Abstract The interleukin (IL)-1 family is a group of cytokines crucially involved in regulating
immune responses to infectious challenges and sterile insults. The family consists of the …

The treatment approach to rheumatoid arthritis has undergone a major evolutionary change
in recent years in part as a consequence of growing appreciation of the severity of this …