DAMPs as mediators of sterile inflammation in aging-related pathologies
N Feldman, A Rotter-Maskowitz, E Okun - Ageing research reviews, 2015 - Elsevier
Accumulating evidence indicates that aging is associated with a chronic low-level
inflammation, termed sterile-inflammation. Sterile-inflammation is a form of pathogen-free …
inflammation, termed sterile-inflammation. Sterile-inflammation is a form of pathogen-free …
DAMPs activating innate immune responses in sepsis
JW Kang, SJ Kim, HI Cho, SM Lee - Ageing research reviews, 2015 - Elsevier
Sepsis refers to the deleterious and non-resolving systemic inflammatory response of the
host to microbial infection and is the leading cause of death in intensive care units. The …
host to microbial infection and is the leading cause of death in intensive care units. The …
DAMPening inflammation by modulating TLR signalling
AM Piccinini, KS Midwood - Mediators of inflammation, 2010 - Wiley Online Library
Damage‐associated molecular patterns (DAMPs) include endogenous intracellular
molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules …
molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules …
Danger-associated molecular patterns derived from the extracellular matrix provide temporal control of innate immunity
CW Frevert, J Felgenhauer… - … of Histochemistry & …, 2018 - journals.sagepub.com
It is evident that components of the extracellular matrix (ECM) act as danger-associated
molecular patterns (DAMPs) through direct interactions with pattern recognition receptors …
molecular patterns (DAMPs) through direct interactions with pattern recognition receptors …
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …
[HTML][HTML] DAMPs from cell death to new life
E Vénéreau, C Ceriotti, ME Bianchi - Frontiers in immunology, 2015 - frontiersin.org
Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns …
intracellular molecules released by injured tissues [damage-associated molecular patterns …
DAMPs and DAMP-sensing receptors in inflammation and diseases
M Ma, W Jiang, R Zhou - Immunity, 2024 - cell.com
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …
produced in cellular damage or stress, and they can activate the innate immune system …
DAMPs, PAMPs, and LAMPs in immunity and sterile inflammation
Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic
breakthroughs. However, many inflammatory pathologies remain without specific therapy …
breakthroughs. However, many inflammatory pathologies remain without specific therapy …
Damage-associated molecular patterns and the systemic immune consequences of severe thermal injury
PB Comish, D Carlson, R Kang… - The journal of immunology, 2020 - journals.aai.org
Thermal injury is often associated with a proinflammatory state resulting in serious
complications. After a burn, the innate immune system is activated with subsequent immune …
complications. After a burn, the innate immune system is activated with subsequent immune …
[HTML][HTML] Complexity of danger: the diverse nature of damage-associated molecular patterns
L Schaefer - Journal of Biological Chemistry, 2014 - ASBMB
In reply to internal or external danger stimuli, the body orchestrates an inflammatory
response. The endogenous triggers of this process are the damage-associated molecular …
response. The endogenous triggers of this process are the damage-associated molecular …