hydroxytryptamine (5-HT) is involved in the pathological processes of several liver diseases.
Acute liver injury underlies the development of many liver diseases, but the mechanism …

Previously we found that acute liver injury (ALI) with inflammation caused by carbon
tetrachloride (CCl 4) was associated with the activation of the 5-HT degradation system …

Previously, we found that the 5-HT 2A receptor plays a key role in cell injury. However, the
mechanism by which the 5-HT 2A receptor mediates intracellular processes remains …

Mitochondrial dysfunction has been documented to play a crucial role in the pathogenesis of
liver injury. In the present study, we investigated the role of rotenone, a mitochondrial …

Heme oxygenase-1, a stress-responsive enzyme that catabolizes hemes into carbon
monoxide, biliverdin, and iron, has been shown to play a pivotal role in many physiological …

Reductive metabolism of carbon tetrachloride (CCl4) is thought to cause lipid peroxidation
which results in hepatic injury. Heme oxygenase-1 (HO-1)(EC 1.14. 99.3), the rate-limiting …

A protective effect of Rho-kinase inhibitor on various organ injuries is gaining attention.
Regarding liver injury, Rho-kinase inhibitor is reported to prevent carbon tetrachloride …

Injection of carbon tetrachloride (CCl4) intraperitoneally into model animals induces acute
liver injury mediated by reactive oxygen species (ROS) as normal metabolites in …

Tert-butylhydroquinone (tBHQ) is an antioxidant compound that exhibits cytoprotective effect
in many tissues under pathological condition. However, its role in carbon tetrachloride …

We examined the preventive effect of melatonin on the progression of carbon tetrachloride
(CCl 4)-induced acute liver injury in rats. In rats injected with CCl 4 (1.0 ml/kg body weight) …