Despite advances in the management of patients with diabetes, diabetic nephropathy (DN)
remains the most common cause of end-stage renal disease in the United States and …

Serum uric acid (UA) is taken up by endothelial cells and reduces the level of nitric oxide
(NO) by inhibiting its production and accelerating its degradation. Cytosolic and plasma …

The prevalence of chronic kidney disease (CKD) is increasing worldwide. Although
hyperuricemia has been associated with CKD in many studies, it remains controversial …

Serum uric acid was first noted to be associated with increased BP by Frederick Mohamed in
the 1870s. Although the link was rediscovered periodically over the years, it generally was …

Recent studies in both humans and experimental animals have led to renewed interest in
uric acid and its association with hypertension, cardiovascular events and renal disease …

Epidemiological studies show that hyperuricemia independently predicts the development of
chronic kidney disease (CKD) in individuals with normal kidney function both in the general …

Previous research has investigated whether hyperuricemia serves as an independent risk
factor for cardiovascular and renal diseases. Hyperuricemia is defined as an abnormally …

This review explores the relationship between uric acid or urate and the pathogenesis of
renal impairment. The following points and conclusions are emphasized:(1) uric acid is an …

Hyperuricemia is associated with hypertension, vascular disease, renal disease, and
cardiovascular events. In this report, we review the epidemiologic evidence and potential …

Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in
normal and remnant kidney rats. Background Hyperuricemia has been associated with renal …