The complement system is a critical element of the innate immune system recognizing and
killing, or targeting for destruction, otherwise pathogenic organisms. In addition to triggering …

Increasing evidence suggests that inflammatory and immune components in brain are
important in Alzheimer's disease (AD) and anti-inflammatory and immunotherapeutic …

The brain is considered to be an immune privileged site, because the blood–brain barrier
limits entry of blood borne cells and proteins into the central nervous system (CNS). As a …

The emergence of complement as an important player in normal brain development and
pathological remodelling has come as a major surprise to most scientists working in …

The spectrum of inflammatory diseases is nowadays considered to include diverse diseases
of the central nervous system (CNS). Current evidence suggests that syndromes such as …

Complement inflammation is a major inflammatory mechanism whose function is to promote
the removal of microorganisms and the processing of immune complexes. Numerous …

This review discusses key findings indicating potential roles of the complement (C)-system
in chronic inflammation in Alzheimer's disease (AD) brain. Although there is no means to …

There is increasing evidence from genetic, immunohistochemical, proteomic and
epidemiological studies as well as in model systems that complement activation has an …

The complement system provides an innate defence mechanism against pathogenic
microorganisms. Although viewed for many years as an immune-privileged organ, the …

An estimated 5.7 million Americans suffer from Alzheimer's disease in the United States, with
no disease-modifying treatments to prevent or treat cognitive deficits associated with the …