Induction of foci of altered, γ-glutamyltranspeptidase-positive hepatocytes in carcinogen-treated rats fed a choline-deficient diet

MA Sells, SL Katyal, S Sell, H Shinozuka… - British Journal of …, 1979 - nature.com
A series of experiments was performed to investigate whether, after exposure of rats to a
chemical hepatocarcinogen, feeding a choline-deficient (CD) diet would promote the …

Transformation of a rat liver cell line: neoplastic phenotype and regulation of gamma glutamyl transpeptidase in tumour tissue

S Sinha, LJ Hockin, GE Neal - Cancer letters, 1987 - Elsevier
A continuously dividing but non-transformed rat cell line was transformed by ras oncogenes
and by aflatoxin. Transformed lines grew as solid tumours in nude mice with a short latency …

Activities of Benzphetamine N-Demethylase and Aryl Hydrocarbon Hydroxylase in Cells Isolated From γ-Glutamyl Transpeptidase-Positive Foci and Surrounding …

MH Hanigan, HC Pitot - Journal of the National Cancer Institute, 1985 - academic.oup.com
The levels of two cytochrome P-450-linked enzymes of xenobiotic metabolism,
benzphetamine N-demethylase and aryl hydrocarbon hydroxylase, were determined in cells …

Clonal Isolation of Populations of γ-Glutamyl Transpeptidase-positive and -negative Cells from Rat Liver Epithelial Cells Chemically Transformed in Vitro

MS Tsao, JW Grisham, BB Chou, JD Smith - Cancer research, 1985 - AACR
In a population of cultured rat liver epithelial cells transformed by 11 brief treatments with N-
methyl-N′-nitro-N-nitrosoguanidine, 9% of the cells stained intensely for γ-glutamyl …

Inhibition of Cell Proliferation by Ciprofibrate in Glutathione S-Transferase P1-1-positive Rat Hepatic Hyperplastic Nodules

ZY Chen, YF Liu, CY He, CC White, DL Eaton - Cancer research, 1994 - AACR
Previous studies have demonstrated that short-term treatment with a peroxisome proliferator
(PP) decreased the size and number of genotoxic carcinogen-induced hepatic hyperplastic …

Immunohistochemical detection of gamma-glutamyl transpeptidase in normal human tissue.

MH Hanigan, HF Frierson Jr - Journal of Histochemistry & …, 1996 - journals.sagepub.com
We developed a new, highly specific antibody that localizes gamma-glutamyl transpeptidase
(GGT) in formalin-fixed sections of human tissue. The specificity of the antibody, GGT129, is …

Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their …

P Greaves, E Irisarri, AM Monro - Journal of the National Cancer …, 1986 - academic.oup.com
The histologic appearance and cytochemical characteristics of foci of hepatic cellular
alteration, hepatic nodules, and hepatocellular carcinomas occurring in male Sprague …

Histochemical characteristics of spontaneous and chemically induced hepatocellular neoplasms in mice and the development of neoplasms with γ-glutamyl …

T Ohmori, JM Rice, GM Williams - The Histochemical Journal, 1981 - Springer
The histochemical characteristics of spontaneous hepatocellular neoplasms in mice of both
sexes were examined and compared with those of hepatocellular neoplasms induced in …

Differences in rat liver enzyme-altered foci produced by chlorinated aliphatics and phenobarbital

DL Story, EF Meierhenry, CA Tyson… - … and Industrial Health, 1986 - journals.sagepub.com
Nine chlorinated aliphatics (CAs)—1, 1-dichloroethane, 1, 2-dichloro ethane, 1, 1, 1-
trichloroethane, 1, 1, 2-trichloroethane, trichloro ethylene, tetrachloroethylene, 1, 1, 1, 2 …

Inhibition of phenobarbital and dietary choline deficiency promoted preneoplastic lesions in rat liver by environmental contaminant di (2-ethylhexyl) phthalate

AB DeAngelo, CT Garrett, AE Queral - Cancer letters, 1984 - Elsevier
The effect of di (2-ethylhexyl) phthalate (DEHP), a widely used plasticizer and environmental
contaminant, on the emergence of gamma-glutamyltranspeptidase positive (GGT+) …