Colocalization of GPR120 with phospholipase-Cβ2 and α-gustducin in the taste bud cells in mice

S Matsumura, A Eguchi, T Mizushige, N Kitabayashi… - Neuroscience …, 2009 - Elsevier
A recent study has demonstrated that the G-protein coupled receptor GPR120 is expressed
in the taste bud cells in rats. In this study, we have identified the types of taste cell that …

GPR expression in the rat taste bud relating to fatty acid sensing

S Matsumura, T Mizushige, T Yoneda… - Biomedical …, 2007 - jstage.jst.go.jp
We investigated the expression of G protein-coupled receptor GPR40 and GPR120 in the rat
tongue. Using reverse transcription polymerase chain reaction, we detected a significant …

Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice

N Godinot, K Yasumatsu, ME Barcos, N Pineau… - Neuroscience, 2013 - Elsevier
There is mounting evidence that, in addition to texture and olfaction, taste plays a role in the
detection of long chain fatty acids. Triglycerides, the main components of oils and dietary fat …

RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells

L Von Buchholtz, A Elischer, E Tareilus… - European Journal of …, 2004 - Wiley Online Library
G‐protein‐mediated signalling processes are involved in sweet and bitter taste transduction.
In particular, the G protein α‐subunit gustducin has been implicated in these processes. One …

The G-protein− coupled receptor GPR40 directly mediates long-chain fatty acid− induced secretion of cholecystokinin

AP Liou, X Lu, Y Sei, X Zhao, S Pechhold, RJ Carrero… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS:: Long-chain fatty acid receptors G-protein− coupled receptor 40
(GPR40)(FFAR1) and GPR120 have been implicated in the chemosensation of dietary fats. I …

Taste preference for fatty acids is mediated by GPR40 and GPR120

C Cartoni, K Yasumatsu, T Ohkuri… - Journal of …, 2010 - Soc Neuroscience
The oral perception of fat has traditionally been considered to rely mainly on texture and
olfaction, but recent findings suggest that taste may also play a role in the detection of long …

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids

CP Briscoe, M Tadayyon, JL Andrews… - Journal of Biological …, 2003 - ASBMB
GPR40 is a member of a subfamily of homologous G protein-coupled receptors that include
GPR41 and GPR43 and that have no current function or ligand ascribed. Ligand fishing …

Discovery of three novel G-protein-coupled receptor genes

BF O'Dowd, T Nguyen, A Marchese, R Cheng… - Genomics, 1998 - Elsevier
We report here the molecular cloning, tissue distribution, and chromosomal localization of
novel genes encoding G-protein-coupled receptors (GPCRs). A search of a mouse database …

Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion

K Iwasaki, N Harada, K Sasaki, S Yamane, K Iida… - …, 2015 - academic.oup.com
Gastric inhibitory polypeptide (GIP) is an incretin secreted from enteroendocrine K cells in
response to meal ingestion. Recently free fatty acid receptor G protein-coupled receptor …

Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion

SJ Paulsen, LK Larsen, G Hansen, S Chelur… - PloS one, 2014 - journals.plos.org
Stimulation of the G protein coupled receptor GPR120 has been shown to have anti-
inflammatory and insulin-sensitizing effects, to promote glucagon like peptide-1 (GLP-1) …