Previous work has demonstrated the important role of E2F transcription activity in the
induction of S phase during the transition from quiescence to proliferation. In addition to the …

The transcription factor E2F plays an important role in G 1 to S phase transition in the higher
eukaryotic cell cycle. Although a number of E2F-inducible genes have been identified, the …

Abstract p21 is a potent inhibitor of cyclin-dependent kinases capable of arresting cell cycle
progression. p21 is primarily regulated at the transcriptional level by several transcription …

E2F-1, the first gene product identified among a family of E2F transcription factors, is thought
to play a critical role in G1/S progression of the cell cycle. Transcriptional activities of E2F …

E2F is a family of transcription factors that regulate both cellular proliferation and
differentiation. To establish the role of E2F3 in vivo, we generated an E2f3 mutant mouse …

Various experiments have demonstrated a role for the E2F transcription factor in the
regulation of cell growth during the G0/G1/S phase transition. Indeed, overexpression of the …

Functional inactivation of the pRB pathway is a very frequent event in human cancer,
resulting in deregulated activity of the E2F transcription factors. To understand the functional …

The E2F family of transcription factors are essential for the regulation of genes required for
appropriate progression through the cell cycle. Five members of the E2F family have been …

The E2F transcription factors are essential for regulating the correct timing of activation of
several genes whose products are implicated in cell proliferation and DNA replication. The …

E2F transcription activity has been shown to play a critical role in cell growth control,
regulating the expression of a variety of genes that encode proteins important for the …