Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer's disease
MK Lai, SW Tsang, JT Alder, J Keene, T Hope… - …, 2005 - Springer
Rationale Previous studies have demonstrated reductions of serotonin 5-HT 2A receptors in
the neocortex of Alzheimer's disease (AD) patients. However, it is unclear whether such …
the neocortex of Alzheimer's disease (AD) patients. However, it is unclear whether such …
[HTML][HTML] Differential involvement of 5-HT1B/1D and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease
M Garcia-Alloza, WD Hirst, CP Chen… - …, 2004 - nature.com
Growing evidence suggests that a compromised serotonergic system plays an important role
in the pathophysiology of Alzheimer's disease (AD). We assessed the expression of 5-HT …
in the pathophysiology of Alzheimer's disease (AD). We assessed the expression of 5-HT …
Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease
MKP Lai, SW Tsang, MM Esiri, PT Francis… - …, 2011 - Springer
Rationale Previous studies have shown extensive serotonergic deficits in the hippocampus
of Alzheimer's disease (AD) patients. However, it is unclear whether such deficits play a role …
of Alzheimer's disease (AD) patients. However, it is unclear whether such deficits play a role …
Reduced 5-HT2A receptor binding in patients with mild cognitive impairment
Previous studies of patients with Alzheimer's disease (AD) have described reduced brain
serotonin 2A (5-HT2A) receptor density. It is unclear whether this abnormality sets in early in …
serotonin 2A (5-HT2A) receptor density. It is unclear whether this abnormality sets in early in …
Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined [11C] DASB and [18F] altanserin-PET study
L Marner, VG Frokjaer, J Kalbitzer, S Lehel… - Neurobiology of …, 2012 - Elsevier
In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed
early and prominent reductions in cerebral serotonin 2A (5-HT2A) receptors. To establish if …
early and prominent reductions in cerebral serotonin 2A (5-HT2A) receptors. To establish if …
Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease
MKP Lai, SWY Tsang, PT Francis, MM Esiri, J Keene… - Brain research, 2003 - Elsevier
Previous studies have implicated brain serotonin 5-HT1A receptors in several CNS
functions, including cognition, mood and emotional states. In Alzheimer disease (AD) …
functions, including cognition, mood and emotional states. In Alzheimer disease (AD) …
[HTML][HTML] Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients
Background It has been hypothesized that alterations of the serotonergic system contribute
to neuropsychiatric symptoms in Alzheimer disease (AD). Cellular expressions of the two …
to neuropsychiatric symptoms in Alzheimer disease (AD). Cellular expressions of the two …
The reduction of baseline serotonin 2A receptors in mild cognitive impairment is stable at two-year follow-up
L Marner, GM Knudsen, K Madsen… - Journal of …, 2011 - content.iospress.com
We previously demonstrated a 20–30% reduction in cortical 5-HT2A receptor binding in
patients with mild cognitive impairment (MCI) as compared to healthy subjects. Here we …
patients with mild cognitive impairment (MCI) as compared to healthy subjects. Here we …
Regional distribution and behavioral correlates of 5-HT2A receptors in Alzheimer's disease with [18F] deuteroaltanserin and PET
L Santhosh, KM Estok, RS Vogel, GD Tamagnan… - Psychiatry Research …, 2009 - Elsevier
Postmortem studies show reductions in brain serotonin 2A (5-HT2A) receptors in
Alzheimer's disease (AD). Converging evidence also suggests that serotonergic …
Alzheimer's disease (AD). Converging evidence also suggests that serotonergic …
A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer disease
Objective The important role of serotonin-1A (5-hydroxytryptamine-1A [5-HT 1A]) receptors
in cognition, behavior, and drug response is increasingly being recognized. Postmortem …
in cognition, behavior, and drug response is increasingly being recognized. Postmortem …