Evidence accumulates suggesting a complex interplay between neurodegenerative
processes and serotonergic neurotransmission. We have previously reported an …

Abstract Alterations in serotonin (5-HT) function have been hypothesized to underlie a range
of physiological, emotional, and cognitive changes in older age. Here, we conducted a …

Alzheimer's disease (AD) is the most common cause of dementia in elderly people. Because
of the lack of effective treatments for this illness, research focused on identifying compounds …

Abstract Using 18 [18F] setoperone and positron emission tomography (PET), alterations in
serotonergic 5-HT2 receptor binding were studied in cerebral cortex of nine unmedicated …

Growing evidence indicates that antagonists of the 5-hydroxytryptamine (serotonin) receptor
6 (5-HT 6) improve memory and reverse amnesia, although the mechanisms involved are …

Animal studies and pharmacological studies in man have suggested that the serotonin 5-
HT1A receptor may serve as a biomarker for cognitive functioning and a target for treatment …

Hyperphagia and associated eating changes occur frequently in Alzheimer's disease (AD)
and lead to considerable morbidity. However, the neurochemical basis for these …

Positron emission tomography (PET) and [11C] WAY-100635 were used to examine the
effect of age on serotonin-1A (5-HT1A) receptor binding potential (BP) in 19 healthy …

The indolamine, serotonin (5-hydroxytryptamine-5-HT) was identified and initially
characterized around the middle of the twentieth century and it is now known to participate in …

The 5-HT1A receptor has been extensively studied over the last two decades. There is a
plethora of information describing its anatomical, physiological and biochemical roles in the …