Introduction: Despite recent advances in Alzheimer's disease (AD) research, no
breakthrough treatments have been discovered. Cholinesterase inhibitors and the NMDA …

We assessed the activity of F15599, a selective and high efficacy 5-HT1A agonist that
preferentially activates post-versus pre-synaptic receptors, in rat cognition/memory models …

Patients suffering from dementia of Alzheimer's type express less serotonin 4 receptors (5-
HTR4), but whether an absence of these receptors modifies learning and memory is …

Importance The cerebral serotonin 4 (5-HT 4) receptor is a promising novel target for
treatment of major depressive disorder (MDD), and pharmacological stimulation of the 5-HT …

OBJECTIVE: In the cortex of animals, serotonin (5-HT) levels increase after several weeks of
treatment with selective serotonin reuptake inhibitors (SSRIs). Studies using an intrasubject …

Autoradiographic analysis of 5-HT 2 receptors in the human brain, using [3 H] ketanserin as
a ligand, reveals region-specific changes in receptor labeling as a function of age. In the …

Antagonism of the 5-HT 6 receptor is a promising approach for the symptomatic treatment of
Alzheimer's disease (AD). There is compelling preclinical evidence for the procognitive …

As a result of its presence in various structures of the central nervous system serotonin (5-
HT) plays a role in a great variety of behaviours such as food intake, activity rythms, sexual …

We assessed the relation between serotonin 5-HT2 receptor availability and aging and
compared it with that for dopamine D2 receptors on 19 healthy male volunteers (age range …

In early Alzheimer's disease, which initially presents with progressive loss of short-term
memory, neurodegeneration especially affects cholinergic neurons of the basal forebrain …