Nitric oxide (NO) is a relative newcomer to pharmacology, as the paper which initiated the
field was published only 25 years ago. Nevertheless its impact is such that to date more than …

Nitric oxide (NO) is a pivotal signaling messenger in the cardiovascular system. NO
participates in regulatory functions including control of hemostasis, fibrinolysis, platelet and …

Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three
distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and …

Nitric oxide (NO) is a structurally simple, highly versatile molecule that was originally
discovered over 30 years ago as an endothelium-derived relaxing factor. In addition to its …

The vascular endothelium is a monolayer of cells between the vessel lumen and the
vascular smooth muscle cells. Nitric oxide (NO) is a soluble gas continuously synthesized …

The endothelium is a single cell layer that lines all blood vessels. This tissue produces an
impressive array of paracrine factors that maintain vascular homeostasis. One of these …

In retrospect, basic research in the fields of nitric oxide (NO) and cyclic guanosine
monophosphate (cGMP) during the past two decades appears to have followed a logical …

This review describes the ability of certain diseases, such as essential hypertension,
atherosclerosis, angina, and vasospasm, to reduce vascular nitric oxide (NO) formation or to …

In contrast with the short research history of the enzymatic synthesis of nitric oxide (NO), the
introduction of nitrate‐containing compounds for medicinal purposes marked its 150th …

Nitric oxide (NO) is a molecule that has gained recognition as a crucial modulator of
vascular disease. NO has a number of intracellular effects that lead to vasorelaxation …