Amiodarone has been used in cardiology for more than 20 years as an anti-angina and anti-
arrhythmia agent. In the seventies, variations in thyroid hormone and TSH concentrations …

Amiodarone blocks the action of thyroid hormone by the inhibition of 5′-deiodinase which
reduces production of T 3 in peripheral tissues and possibly by blocking nuclear binding of T …

The author presents his experience with the thyroid complications of amiodarone therapy:
exceptional but sometimes serious conditions. Both, hypo-and hyperthyroidism can occur …

In order to evaluate the effects of amiodarone on thyroid function in chronically treated
patients, 43 consecutive patients, who had been taking a mean weekly dose of 1420±488 …

The effects of amiodarone on thyroid function tests in 100 patients treated for 6 weeks to 8
years are reported. One patient became thyrotoxic and 10 developed latent or overt …

Both hyperthyroidism and hypothyroidism have been noted to occur in some patients treated
with amiodarone for cardiac arrhythmias. To determine the frequency of the development of …

World-wide, the incidence of amiodarone-induced thyroid dysfunction is estimated to be
between 2% and 24%. More than 50% of patients who receive long-term amiodarone have …

The frequency of dysthyroidism during treatment with amiodarone makes it necessary to
watch the thyroid gland, especially since that organ may apparently be intact in such cases …

Of a population of 400 patients treated with amiodarone, 97 underwent thyroid function
evaluation. Of these, 20 patients proved to be thyrotoxic and 16 hypothyroid. In thyrotoxic …

Amiodarone has been reported as an anti-anginal drug in 19h7 [11 and as an anti-
arrhythmic drug in 1969 [2]. Thyroid side-effects (hypothyroidism and thyrotoxicosis) were …