Small aromatic ring systems are of central importance in the development of novel synthetic
protein ligands. Here we generate a complete list of 24847 such ring systems. We call this …

We have analyzed the rings, ring systems, and frameworks in drugs listed in the FDA
Orange Book to understand the frequency, timelines, molecular property space, and the …

Covering: up to 2021 The structural core of most small-molecule drugs is formed by a ring
system, often derived from natural products. However, despite the importance of natural …

Bioactive molecules only contain a relatively limited number of unique ring types. To identify
those ring properties and structural characteristics that are necessary for biological activity, a …

We present a comprehensive analysis of all ring systems (both heterocyclic and
nonheterocyclic) in clinical trial compounds and FDA-approved drugs. We show 67% of …

Natural products and their molecular frameworks have a long tradition as valuable starting
points for medicinal chemistry and drug discovery. Recently, there has been a revitalization …

Nature has exploited medium-sized 8-to 11-membered rings in a variety of natural products
to address diverse and challenging biological targets. However, owing to the limitations of …

Privileged structures inspire compound library design in medicinal chemistry. We performed
a comprehensive analysis of 1.4 million bioactive compounds, with the aim of assessing the …

Contemporary medicinal chemistry faces diverse challenges from several directions,
including the need for both potency and specificity of any therapeutic agent; the increasingly …

Spirocycles frequently occur in natural products and experience increasing interest in drug
discovery, given their richness in sp3 centers and distinct three‐dimensionality. We have …