“Are we not going too far?“: Socio-ethical considerations of preimplantation genetic testing using polygenic risk scores according to healthcare professionals

M Siermann, O Valcke, JR Vermeesch, T Raivio… - Social Science & …, 2024 - Elsevier
The recent introduction of polygenic risk scores within preimplantation genetic testing (PGT-
P) has been met with many concerns. To get more insights into the perspectives of relevant …

Limitations, concerns and potential: attitudes of healthcare professionals toward preimplantation genetic testing using polygenic risk scores

M Siermann, O Valcke, JR Vermeesch… - European Journal of …, 2023 - nature.com
Preimplantation genetic testing using polygenic risk scores (PGT-P) has recently been
introduced. However, PGT-P has been met with many ethical concerns. It is therefore …

Ready for polygenic risk scores? An analysis of regulation of preimplantation genetic testing in European countries

M Siermann, V van der Schoot, EM Bunnik… - Human …, 2024 - academic.oup.com
STUDY QUESTION Would the different regulatory approaches for preimplantation genetic
testing (PGT) in Europe permit the implementation of preimplantation genetic testing using …

[HTML][HTML] A review of normative documents on preimplantation genetic testing: recommendations for PGT-P

M Siermann, O Tšuiko, JR Vermeesch, T Raivio… - Genetics in …, 2022 - Elsevier
Purpose Recently, preimplantation genetic testing (PGT) for polygenic conditions (PGT-P)
has been introduced commercially. In view of the lack of specific guidance on this …

A systematic review of the views of healthcare professionals on the scope of preimplantation genetic testing

M Siermann, Z Claesen, L Pasquier, T Raivio… - Journal of Community …, 2022 - Springer
Preimplantation genetic testing (PGT) involves testing embryos created through in vitro
fertilization for the presence of hereditary genetic disorders and chromosome abnormalities …

The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

F Forzano, O Antonova, A Clarke, G de Wert… - European Journal of …, 2022 - nature.com
Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private
testing companies to parents using in vitro fertilisation as being useful in selecting the …

Clinical utility of polygenic risk scores for embryo selection: a points to consider statement of the American College of Medical Genetics and Genomics (ACMG)

TA Grebe, G Khushf, JM Greally, P Turley, N Foyouzi… - Genetics in …, 2024 - Elsevier
Polygenic risk score (PRS) assessment for embryo selection (hereafter referred to as
preimplantation testing for polygenic disorder [PGT-P]) is an emerging reproductive …

The decision-making process, experience, and perceptions of preimplantation genetic testing (PGT) users

S Zuckerman, S Gooldin, DA Zeevi… - Journal of Assisted …, 2020 - Springer
Purpose The decision to undergo preimplantation genetic testing (PGT) entails a variety of
personal and societal variables. Although PGT technology is widely accepted and used, few …

Screening embryos for polygenic conditions and traits: ethical considerations for an emerging technology

G Lázaro-Muñoz, S Pereira, S Carmi, T Lencz - Genetics in Medicine, 2021 - nature.com
Polygenic embryo screening (PES)—the use of polygenic risk scores for complex
phenotypes as a component of preimplantation genetic testing (PGT)—has emerged as a …

A review on the motivations, decision-making factors, attitudes and experiences of couples using pre-implantation genetic testing for inherited conditions

T Hughes, T Bracewell-Milnes, S Saso… - Human …, 2021 - academic.oup.com
BACKGROUND In pre-implantation genetic testing (PGT), fertile couples undergo IVF with
genetic testing of embryos to avoid conceptions with a genetic condition. There is an …