“Are we not going too far?“: Socio-ethical considerations of preimplantation genetic testing using polygenic risk scores according to healthcare professionals
M Siermann, O Valcke, JR Vermeesch, T Raivio… - Social Science & …, 2024 - Elsevier
The recent introduction of polygenic risk scores within preimplantation genetic testing (PGT-
P) has been met with many concerns. To get more insights into the perspectives of relevant …
P) has been met with many concerns. To get more insights into the perspectives of relevant …
Limitations, concerns and potential: attitudes of healthcare professionals toward preimplantation genetic testing using polygenic risk scores
M Siermann, O Valcke, JR Vermeesch… - European Journal of …, 2023 - nature.com
Preimplantation genetic testing using polygenic risk scores (PGT-P) has recently been
introduced. However, PGT-P has been met with many ethical concerns. It is therefore …
introduced. However, PGT-P has been met with many ethical concerns. It is therefore …
Ready for polygenic risk scores? An analysis of regulation of preimplantation genetic testing in European countries
M Siermann, V van der Schoot, EM Bunnik… - Human …, 2024 - academic.oup.com
STUDY QUESTION Would the different regulatory approaches for preimplantation genetic
testing (PGT) in Europe permit the implementation of preimplantation genetic testing using …
testing (PGT) in Europe permit the implementation of preimplantation genetic testing using …
[HTML][HTML] A review of normative documents on preimplantation genetic testing: recommendations for PGT-P
M Siermann, O Tšuiko, JR Vermeesch, T Raivio… - Genetics in …, 2022 - Elsevier
Purpose Recently, preimplantation genetic testing (PGT) for polygenic conditions (PGT-P)
has been introduced commercially. In view of the lack of specific guidance on this …
has been introduced commercially. In view of the lack of specific guidance on this …
A systematic review of the views of healthcare professionals on the scope of preimplantation genetic testing
M Siermann, Z Claesen, L Pasquier, T Raivio… - Journal of Community …, 2022 - Springer
Preimplantation genetic testing (PGT) involves testing embryos created through in vitro
fertilization for the presence of hereditary genetic disorders and chromosome abnormalities …
fertilization for the presence of hereditary genetic disorders and chromosome abnormalities …
The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice
F Forzano, O Antonova, A Clarke, G de Wert… - European Journal of …, 2022 - nature.com
Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private
testing companies to parents using in vitro fertilisation as being useful in selecting the …
testing companies to parents using in vitro fertilisation as being useful in selecting the …
Clinical utility of polygenic risk scores for embryo selection: a points to consider statement of the American College of Medical Genetics and Genomics (ACMG)
Polygenic risk score (PRS) assessment for embryo selection (hereafter referred to as
preimplantation testing for polygenic disorder [PGT-P]) is an emerging reproductive …
preimplantation testing for polygenic disorder [PGT-P]) is an emerging reproductive …
The decision-making process, experience, and perceptions of preimplantation genetic testing (PGT) users
S Zuckerman, S Gooldin, DA Zeevi… - Journal of Assisted …, 2020 - Springer
Purpose The decision to undergo preimplantation genetic testing (PGT) entails a variety of
personal and societal variables. Although PGT technology is widely accepted and used, few …
personal and societal variables. Although PGT technology is widely accepted and used, few …
Screening embryos for polygenic conditions and traits: ethical considerations for an emerging technology
Polygenic embryo screening (PES)—the use of polygenic risk scores for complex
phenotypes as a component of preimplantation genetic testing (PGT)—has emerged as a …
phenotypes as a component of preimplantation genetic testing (PGT)—has emerged as a …
A review on the motivations, decision-making factors, attitudes and experiences of couples using pre-implantation genetic testing for inherited conditions
T Hughes, T Bracewell-Milnes, S Saso… - Human …, 2021 - academic.oup.com
BACKGROUND In pre-implantation genetic testing (PGT), fertile couples undergo IVF with
genetic testing of embryos to avoid conceptions with a genetic condition. There is an …
genetic testing of embryos to avoid conceptions with a genetic condition. There is an …