Diagnosis, pathogenesis and therapeutic targets in amyotrophic lateral sclerosis

J Costa, C Gomes… - CNS & Neurological …, 2010 - ingentaconnect.com
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease of the motor
system. The diagnosis is clinical, but additional investigations such as electromyography …

Roots to start research in amyotrophic lateral sclerosis: molecular pathways and novel therapeutics for future

D Harikrishnareddy, S Misra, S Upadhyay… - Reviews in the …, 2015 - degruyter.com
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease that rapidly
progresses from mild motor symptoms to severe motor paralysis and premature death. There …

Molecular insights and therapeutic targets in amyotrophic lateral sclerosis

A Al-Chalabi, VB Tripathi - CNS & Neurological Disorders-Drug …, 2008 - ingentaconnect.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons
resulting in progressive paralysis and respiratory failure. About 1 in every 400 people dies of …

[HTML][HTML] Current view and perspectives in amyotrophic lateral sclerosis

S Mathis, P Couratier, A Julian, P Corcia… - Neural Regeneration …, 2017 - journals.lww.com
Amyotrophic lateral sclerosis (ALS), identified as a distinct clinical entity by Charcot since the
end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that …

[HTML][HTML] Amyotrophic lateral sclerosis: drug therapy from the bench to the bedside

SB Gibson, MB Bromberg - Seminars in neurology, 2012 - thieme-connect.com
Amyotrophic lateral sclerosis (ALS) is an unrelenting progressive neurodegenerative
disease causing progressive weakness, ultimately leading to death. Despite aggressive …

Prospects for the pharmacotherapy of amyotrophic lateral sclerosis: old strategies and new paradigms for the third millennium

BW Festoff, Z Suo, BA Citron - CNS drugs, 2003 - Springer
Biomedical researchers interested in amyotrophic lateral sclerosis (ALS) must invoke newly
developing technologies if we are to discover pharmaceutical treatments that will help a …

Potential therapeutic drugs and methods for the treatment of amyotrophic lateral sclerosis

G Yacila, Y Sari - Current medicinal chemistry, 2014 - ingentaconnect.com
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder caused by damage of
motoneurons leading to paralysis state and long term disability. Riluzole is currently the only …

Therapeutic neuroprotective agents for amyotrophic lateral sclerosis

RS Pandya, H Zhu, W Li, R Bowser… - Cellular and molecular …, 2013 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal chronic neurodegenerative disease whose
hallmark is proteinaceous, ubiquitinated, cytoplasmic inclusions in motor neurons and …

Emerging drugs for the treatment of amyotrophic lateral sclerosis: a focus on recent phase 2 trials

A Barp, F Gerardi, A Lizio, VA Sansone… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative
disease involving both upper and lower motor neurons and resulting in increasing disability …

Emerging drugs for amyotrophic lateral sclerosis

AA Habib, H Mitsumoto - Expert opinion on emerging drugs, 2011 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative
disease that results in increasing disability and that is uniformly fatal. Since its approval in …