Abstract Phosphodiesterase 5 (PDE 5) inhibitors are selective inhibitors of the enzyme PDE
5, which catalyzes the hydrolysis of cyclic guanosine monophosphate (cGMP), a potent …

J Clin Hypertens (Greenwich). 2012; 14: 644–649.© 2012 Wiley Periodicals, Inc.
Phosphodiesterase 5 (PDE‐5) inhibitors are selective blockers of PDE‐5, which catalyzes …

Phosphodiesterase type-5 (PDE-5) is an enzyme that catalyzes the hydrolytic degradation of
cyclic GMP–an essential intracellular second messenger that modulates diverse biological …

Phosphodiesterase (PDE) 5 inhibitors reduce cyclic guanylate monophosphate breakdown,
promoting vascular relaxation in the corpora cavernosa and penile erection during sexual …

Phosphodiesterase type 5 (PDE5) is one member of a superfamily of cyclic nucleotide
hydrolyzing enzymes that specifically cleaves cyclic guanosine monophosphate (cGMP), a …

As a potent and selective inhibitor of cyclic guanosine monophosphate‐specific
phosphodiesterase 5 (PDE5), sildenafil citrate (Viagra®) is safe and effective in men with …

Since the discovery of sildenafil in 1989 as a highly selective inhibitor of the
phosphodiesterase type-5 (PDE-5) receptor, 2 additional PDE-5 inhibitors, tadalafil and …

The usefulness of selective inhibitors of phosphodiesterase 5 (PDE5) is well known, first for
the treatment of male erectile dysfunction and more recently for pulmonary hypertension …

Introduction: At the present time, inhibitors of phosphodiesterase type 5 (PDE5) have Food
and Drug Administration approval only for the treatment of erectile dysfunction and …

Introduction: The inhibition of cyclic nucleotide PDE5 has been clinically validated as an
effective treatment for erectile dysfunction and pulmonary arterial hypertension. There are …