Regulation of stress responses and translational control by coronavirus

TS Fung, Y Liao, DX Liu - Viruses, 2016 - mdpi.com
Similar to other viruses, coronavirus infection triggers cellular stress responses in infected
host cells. The close association of coronavirus replication with the endoplasmic reticulum …

[HTML][HTML] Coronavirus infection, ER stress, apoptosis and innate immunity

TS Fung, DX Liu - Frontiers in microbiology, 2014 - frontiersin.org
The replication of coronavirus, a family of important animal and human pathogens, is closely
associated with the cellular membrane compartments, especially the endoplasmic reticulum …

Coronavirus-induced ER stress response and its involvement in regulation of coronavirus–host interactions

TS Fung, M Huang, DX Liu - Virus research, 2014 - Elsevier
Coronavirus replication is structurally and functionally associated with the endoplasmic
reticulum (ER), a major site of protein synthesis, folding, modification and sorting in the …

The PERK arm of the unfolded protein response negatively regulates transmissible gastroenteritis virus replication by suppressing protein translation and promoting …

M Xue, F Fu, Y Ma, X Zhang, L Li, L Feng… - Journal of virology, 2018 - Am Soc Microbiol
Coronavirus replication is closely associated with the endoplasmic reticulum (ER), the
primary cellular organelle for protein synthesis, folding, and modification. ER stress is a …

Translational control of coronaviruses

S De Breyne, C Vindry, O Guillin, L Condé… - Nucleic Acids …, 2020 - academic.oup.com
Coronaviruses represent a large family of enveloped RNA viruses that infect a large
spectrum of animals. In humans, the severe acute respiratory syndrome coronavirus type 2 …

[HTML][HTML] The role of unfolded protein response in coronavirus infection and its implications for drug design

M Xue, L Feng - Frontiers in microbiology, 2021 - frontiersin.org
Coronavirus is an important pathogen with a wide spectrum of infection and potential threats
to humans and animals. Its replication occurs in the cytoplasm and is closely related to the …

[HTML][HTML] Move and countermove: the integrated stress response in picorna-and coronavirus-infected cells

C Aloise, JG Schipper, RJ de Groot… - Current Opinion in …, 2022 - Elsevier
Highlights•The integrated stress response (ISR) is an adaptive pathway activated by various
stressors, including virus infection.•ISR activation culminates in translation arrest through …

Coronavirus infection modulates the unfolded protein response and mediates sustained translational repression

J Bechill, Z Chen, JW Brewer, SC Baker - Journal of virology, 2008 - Am Soc Microbiol
During coronavirus replication, viral proteins induce the formation of endoplasmic reticulum
(ER)-derived double-membrane vesicles for RNA synthesis, and viral structural proteins …

Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies

M Raaben, MJA Groot Koerkamp… - Cellular …, 2007 - Wiley Online Library
Many viruses, including coronaviruses, induce host translational shutoff, while maintaining
synthesis of their own gene products. In this study we performed genome‐wide microarray …

Coronavirus takeover of host cell translation and intracellular antiviral response: a molecular perspective

ED Karousis, K Schubert, N Ban - The EMBO journal, 2024 - embopress.org
Coronaviruses are a group of related RNA viruses that cause respiratory diseases in
humans and animals. Understanding the mechanisms of translation regulation during …