Iron is an essential metal involved in several major cellular processes required to maintain
life. Because of iron's ability to cause oxidative damage, its transport, metabolism, and …

Iron is required for key aspects of cellular physiology including mitochondrial function and
DNA synthesis and repair. However, free iron is an aberration because of its ability to donate …

Iron is an essential element that is indispensable for life. The delicate physiological body
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …

Background: Iron is critical for fundamental biologic functions such as cell division and
mitochondrial electron transport. However, by the virtue of its ability to donate electrons, iron …

Ferritin plays a central role in iron metabolism and is made of 24 subunits of 2 types: heavy
chain and light chain. The ferritin heavy chain (FtH) has ferroxidase activity that is required …

Acute kidney injury (AKI) is a common and often devastating condition among hospitalized
patients and is associated with markedly increased hospital length of stay, mortality, and …

Iron-mediated oxidative stress is implicated in the pathogenesis of renal ischemia–
reperfusion injury. Hepcidin is an endogenous acute phase hepatic hormone that prevents …

In the past 8 years, there has been renewed interest in the role of iron in both acute kidney
injury (AKI) and chronic kidney disease (CKD). In patients with kidney diseases, renal …

Chronic kidney disease is increasing at an alarming rate and correlates with the increase in
diabetes, obesity, and hypertension that disproportionately impact socioeconomically …

Renal iron recycling preserves filtered iron from urinary excretion. However, it remains
debated whether ferroportin (FPN), the only known iron exporter, is functionally involved in …