[HTML][HTML] Comprehensive molecular characterization reveals genomic and transcriptomic subtypes of metastatic urothelial carcinoma

JA Nakauma-González, M Rijnders, J van Riet… - European urology, 2022 - Elsevier
Recent molecular characterization of primary urothelial carcinoma (UC) may guide future
clinical decision-making. For metastatic UC (mUC), a comprehensive molecular …

[HTML][HTML] Molecular urothelial tumor cell subtypes remain stable during metastatic evolution

A Cox, N Klümper, J Stein, D Sikic, J Breyer, C Bolenz… - European Urology, 2024 - Elsevier
Urothelial cancer (UC) care is moving toward precision oncology. For tumor biology–driven
treatment of metastatic UC (mUC), molecular subtypes play a crucial role. However, it is not …

[HTML][HTML] Genomic distinctions between metastatic lower and upper tract urothelial carcinoma revealed through rapid autopsy

BR Winters, N De Sarkar, S Arora, H Bolouri, S Jana… - JCI insight, 2019 - ncbi.nlm.nih.gov
BACKGROUND Little is known about the genomic differences between metastatic lower
tract urothelial carcinoma (LTUC) and upper tract urothelial carcinoma (UTUC). We compare …

Collaborative study from the Bladder Cancer Advocacy Network for the genomic analysis of metastatic urothelial cancer

JS Damrauer, W Beckabir, J Klomp, M Zhou… - Nature …, 2022 - nature.com
Abstract Urothelial Cancer-Genomic Analysis to Improve Patient Outcomes and Research
(NCT02643043), UC-GENOME, is a genomic analysis and biospecimen repository study in …

Metastasis and recurrence patterns in the molecular subtypes of urothelial bladder cancer

G Sjödahl, P Eriksson, K Holmsten… - … Journal of Cancer, 2024 - Wiley Online Library
Urothelial cancer of the urinary bladder frequently metastasizes to lymph‐nodes, lungs, liver
and bone. A taxonomy for molecular classification exists, but it is unknown if molecular …

The evolution of metastatic upper tract urothelial carcinoma through genomic-transcriptomic and single-cell protein markers analysis

K Ohara, AF Rendeiro, B Bhinder, KW Eng… - Nature …, 2024 - nature.com
The molecular characteristics of metastatic upper tract urothelial carcinoma (UTUC) are not
well understood, and there is a lack of knowledge regarding the genomic and transcriptomic …

[HTML][HTML] Molecular characterization of urothelial carcinoma of the bladder and upper urinary tract

JY Lee, K Kim, HH Sung, HG Jeon, BC Jeong… - Translational …, 2018 - Elsevier
PURPOSE: A better understanding of the molecular basis of urothelial carcinoma (UC) is
needed to refine the clinical decision-making process. METHODS AND MATERIALS: We …

Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy

JS Ross, K Wang, RN Al-Rohil, T Nazeer… - Modern …, 2014 - nature.com
Although urothelial carcinoma (UC) of the urinary bladder generally portends a favorable
prognosis, metastatic tumors often follow an aggressive clinical course. DNA was extracted …

Characterization of metastatic urothelial carcinoma via comprehensive genomic profiling of circulating tumor DNA

N Agarwal, SK Pal, AW Hahn, RH Nussenzveig… - Cancer, 2018 - Wiley Online Library
BACKGROUND Biomarker‐guided clinical trials are increasingly common in metastatic
urothelial carcinoma (mUC), yet patients for whom contemporary tumor tissue is not …

Comprehensive genomic profiling of upper tract urothelial carcinoma and urothelial carcinoma of the bladder identifies distinct molecular characterizations with …

Q Tang, W Zuo, C Wan, S Xiong, C Xu, C Yuan… - Frontiers in …, 2023 - frontiersin.org
Backgrounds Despite the genomic landscape of urothelial carcinomas (UC) patients,
especially those with UC of bladder (UCB), has been comprehensively delineated and …