In the clinical realm, the highest degree of evidence driving practice guidelines originates
from randomised controlled trials (RCTs) and meta-analysis of RCTs. For practice changes …

Cardiovascular disease remains the leading cause of morbidity and mortality in developed
countries. Obstructive sleep apnea is a highly prevalent condition characterized by repetitive …

Background Long-term noninvasive positive airway pressure (PAP) treatment is effective
treatment for sleep-related breathing disorders and chronic hypercarbic respiratory failure …

We aimed to compare the effect of intensive versus standard interventions on continuous
positive airway pressure (CPAP) adherence 2 years after CPAP initiation, as well as on …

Although nasal continuous positive airway pressure (CPAP) is generally effective in
correcting sleep-related respiratory disturbance and associated daytime sequelae in …

Breathing out against resistance, in order to achieve positive expiratory pressure (PEP), is
applied by many patient groups. Pursed lips breathing and a variety of devices can be used …

Rationale: Randomized controlled trials do not support a role for continuous positive airway
pressure (CPAP) in preventing major cardiovascular events or mortality in patients with …

Study Objectives: We sought to provide an updated systematic review and meta-analysis of
studies investigating the effect of positive airway pressure (PAP) treatment for obstructive …

Two recent commentaries, by Aly1 and de Klerk and de Klerk, 2 review the role of
continuous positive airway pressure (CPAP) as an alternative to mechanical ventilation in …

In the era of evidence-based medicine, clinicians draw upon a vast resource of research-
based evidence to guide their practice. However, finding this information is not always easy …