[HTML][HTML] Neural progenitor cells but not astrocytes respond distally to thoracic spinal cord injury in rat models

T Nguyen, Y Mao, T Sutherland… - Neural regeneration …, 2017 - journals.lww.com
Traumatic spinal cord injury (SCI) is a detrimental condition that causes loss of sensory and
motor function in an individual. Many complex secondary injury cascades occur after SCI …

[HTML][HTML] Developmental stage of transplanted neural progenitor cells influences anatomical and functional outcomes after spinal cord injury in mice

M Aceves, A Tucker, J Chen, K Vo, J Moses… - Communications …, 2023 - nature.com
Neural progenitor cell (NPC) transplantation is a promising therapeutic strategy for replacing
lost neurons following spinal cord injury (SCI). However, how graft cellular composition …

Rodent neural progenitor cells support functional recovery after cervical spinal cord contusion

JH Brock, L Graham, E Staufenberg, S Im… - Journal of …, 2018 - liebertpub.com
Previously, we and others have shown that rodent neural progenitor cells (NPCs) can
support functional recovery after cervical and thoracic transection injuries. To extend these …

Neuroectodermal stem cells grafted into the injured spinal cord induce both axonal regeneration and morphological restoration via multiple mechanisms

K Pajer, T Bellák, H Redl, A Nógrádi - Journal of Neurotrauma, 2019 - liebertpub.com
Spinal cord contusion injury leads to severe loss of gray and white matter and subsequent
deficit of motor and sensory functions below the lesion. In this study, we investigated …

Impact of chemokines on the properties of spinal cord‐derived neural progenitor cells in a rat spinal cord lesion model

F Knerlich‐Lukoschus, S Krossa… - Journal of …, 2015 - Wiley Online Library
The existence of endogenous neural progenitor cells (NPCs) in the adult spinal cord (sc)
provides the potential for tailored repair therapies after spinal cord injury (SCI). This study …

[HTML][HTML] Temporal response of endogenous neural progenitor cells following injury to the adult rat spinal cord

Y Mao, K Mathews, CA Gorrie - Frontiers in cellular neuroscience, 2016 - frontiersin.org
A pool of endogenous neural progenitor cells (NPCs) found in the ependymal layer and the
sub-ependymal area of the spinal cord are reported to upregulate Nestin in response to …

Human spinal oligodendrogenic neural progenitor cells enhance pathophysiological outcomes and functional recovery in a clinically relevant cervical spinal cord …

K Pieczonka, H Nakashima, N Nagoshi… - Stem Cells …, 2023 - academic.oup.com
Traumatic spinal cord injury (SCI) results in the loss of neurons, oligodendrocytes, and
astrocytes. Present interventions for SCI include decompressive surgery, anti-inflammatory …

Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury

SS McMahon, S Albermann, GE Rooney, G Shaw… - …, 2010 - Taylor & Francis
Background aims. Spinal cord injury is a devastating injury that impacts drastically on the
victim's quality of life. Stem cells have been proposed as a therapeutic strategy. Neural stem …

Transplanted adult spinal cord–derived neural stem/progenitor cells promote early functional recovery after rat spinal cord injury

AM Parr, I Kulbatski, T Zahir, X Wang, C Yue, A Keating… - Neuroscience, 2008 - Elsevier
We examined the effect of spinal cord–derived neural stem/progenitor cells (NSPCs) after
delayed transplantation into the injured adult rat spinal cord with or without earlier …

Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord

M Cusimano, D Biziato, E Brambilla, M Donega… - Brain, 2012 - academic.oup.com
Transplanted neural stem/precursor cells possess peculiar therapeutic plasticity and can
simultaneously instruct several therapeutic mechanisms in addition to cell replacement …