How can diversity-oriented strategies for chemical synthesis provide chemical tools to help
shape our understanding of complex cancer pathways and progress anti-cancer drug …

Modern drug discovery often involves screening small molecules for their ability to bind to a
preselected protein target. Target-oriented syntheses of these small molecules, individually …

Small molecule modulators of biological function can be discovered by the screening of
compound libraries. However, it became apparent that some human disease related targets …

Diversity-oriented synthesis (DOS) is an emerging field involving the synthesis of
combinatorial libraries of diverse small molecules for biological screening. Rather than …

This chapter introduces the underlying ideas behind diversity‐oriented synthesis (DOS). It
discusses the relationship between DOS, target‐oriented synthesis (TOS), and …

Discover an enhanced synthetic approach to developing and screening chemical compound
libraries Diversity-oriented synthesis is a new paradigm for developing large collections of …

Compounds accessed through diversity-oriented synthesis (DOS) are showing promise in
modulating the activities of several targets that are currently considered 'undruggable' …

Biology-oriented synthesis (BIOS) represents an alternative approach for the generation of
compound collections for biological applications. In BIOS, biologically relevant and …

Small bioactive molecules are pre-requisite for any discovery discipline. Being aware of the
fact that bioactivity is not randomly dispersed in the vast chemical space, chemists have …

Diversity-oriented synthesis has historically focused on the generation of small-molecule
collections with considerable scaffold, stereochemical, and appendage diversity. Recently …