Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges
E Hu, D Lee - Expert Opinion on Therapeutic Targets, 2005 - Taylor & Francis
Rho kinase (ROCK) belongs to a family of Ser/Thr protein kinases that are activated via
interaction with the small GTP-binding protein RhoA. Growing evidence suggests that RhoA …
interaction with the small GTP-binding protein RhoA. Growing evidence suggests that RhoA …
ROCKs as therapeutic targets in cardiovascular diseases
Y Rikitake, JK Liao - Expert review of cardiovascular therapy, 2005 - Taylor & Francis
There is growing evidence that Rho-kinases (ROCKs), the immediate downstream targets of
the small guanosine triphosphate-binding protein Rho, may contribute to cardiovascular …
the small guanosine triphosphate-binding protein Rho, may contribute to cardiovascular …
Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases
The Rho/rho-kinase (ROCK) pathway has an important role in the pathogenesis of several
cardiovascular diseases. The activation of ROCK is involved in the regulation of vascular …
cardiovascular diseases. The activation of ROCK is involved in the regulation of vascular …
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil
Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …
Rho kinase inhibitors as potential therapeutic agents for cardiovascular diseases.
E Hu, D Lee - Current Opinion in Investigational Drugs (London …, 2003 - europepmc.org
RhoA and Rho-kinase (ROCK) participate in diverse cellular signaling functions such as
smooth muscle contraction, cytoskeleton rearrangement, and cell migration and …
smooth muscle contraction, cytoskeleton rearrangement, and cell migration and …
Rho kinase signaling and cardiac physiology
Highlights•Rho kinase signaling plays important roles in the cardiovascular system.•Rho
kinase signaling mediates cardiac hypertrophy, apoptosis and fibrosis.•Rho kinase signaling …
kinase signaling mediates cardiac hypertrophy, apoptosis and fibrosis.•Rho kinase signaling …
Rho kinase (ROCK) inhibitors
JK Liao, M Seto, K Noma - Journal of cardiovascular …, 2007 - journals.lww.com
The Rho kinase (ROCK) isoforms, ROCK1 and ROCK2, were initially discovered as
downstream targets of the small GTP-binding protein Rho. Because ROCKs mediate various …
downstream targets of the small GTP-binding protein Rho. Because ROCKs mediate various …
Current status of rho-associated kinases (ROCKs) in coronary atherosclerosis and vasospasm
M Dong, BP Yan, CM Yu - Cardiovascular & Hematological …, 2009 - ingentaconnect.com
Rho-kinase (ROCK) is one of the effectors of the small GTP-binding protein Rho.
Accumulating evidence suggests that the Rho/ROCK system may play an important role in …
Accumulating evidence suggests that the Rho/ROCK system may play an important role in …
Development of Rho-kinase inhibitors for cardiovascular medicine
H Shimokawa, M Rashid - Trends in pharmacological sciences, 2007 - cell.com
Rho-kinase (ROCK) is one of the downstream effectors of the small G-protein Rho. The Rho–
ROCK pathway has an important role in mediating various cellular functions, including …
ROCK pathway has an important role in mediating various cellular functions, including …
Rho kinases in cardiovascular physiology and pathophysiology
Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein
RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have …
RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have …